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Dr. Hang Pham joins us virtually for her presentation on uncovering key residues in galectin-7 that control positive cooperativity between two opposite glycan binding sites. Using allosteric network analysis, this work aime to improve GAL-7 selectivity.

Dr. Adam Damry (Adam Damry) electrifies the session with his work on the electrodetection of small molecules by conformation-mediated signal enhancement. By developing a novel class of electrochemical biosensors, Dr. Damry seeks to alleviate flaws in current detection platforms.

Closing out our first session today is our 5th keynote speaker, Dr. Gavin Williams (Gavin Williams). Dr. Williams describes a program of enzyme engineering, directed evo, and synbio aiming to make natural products with unnatural functionality. Thanks for joining us, Dr. Williams!

Fueled by a quick coffee, Cody Krivacic speaks on his work on HELIX: a bottom-up method for designing protein binders de novo. HELIX is designed to add a key tool in the design of new biologics and protein circuits.

Dr. Jeliazko Jeliazkov joins us over Zoom to present his work on protein language models for recombinant expression prediction & codon optimization. Achieving success on a test set of proteins in E coli, this method aims to give the problem of protein expression to deep learners.

Dr. Joelle Pelletier presents her work on understanding the mechanisms behind the powerful antibiotic resistance function of bacterial DfrBs. The evolution of a SH3-like fold confers unusual properties contribute to the power of these resistance proteins.

Our 6th keynote, Dr. Dek Woolfson (Dek Woolfson), closes out our morning with a challenge: can we design proteins beyond nature's templates & target the "protein dark matter"? Thanks to Dr. Woolfson for sharing his work on this leap into a new frontier of protein design! #PEC2022

Dr Jeliazko Jeliazkov joins us over Zoom to present his work on protein language models for recombinant expression prediction & codon optimization. Achieving success in a test set of proteins in E. coli, this method aims to give the problem of protein expression to deep learners.

This afternoon starts with our 7th keynote by Dr. Bruno Correia (Bruno Correia). He takes us back to the "protein dark matter" with MaSIF, a conceptual framework based on deep learning to design de novo protein-protein interactions. Pleasure to listen, Dr. Correia! #PEC2022

Adding another tool against SARS-CoV2, Dr. Wael Rabeh speaks on his work to identify inhibitors to the virus' main protease. Guided by structure, dimerization of the protease was prevented which inhibited its activity, opening the door to new ways to design antivirals. #PEC2022

Dr. Julia Shifman continues the afternoon with her work on converting natural protein effectors into next-gen therapeutics. Engineered inhibitors to known cancer targets demonstrated affinity and specificity, opening the door for this technique to be applied broadly. #PEC2022

Continuing to elucidate SARS-CoV2, Dr. Charlotte Miton (Charlotte Miton) explores the mutability landscape of the virus' N-terminal domain. Characterizing diverse deletions, this work illuminates the forces that shape and constrain mutations within the landscape. #PEC2022

Closing out the 2nd day of #PEC2022 is our 8th keynote by Dr. Andreas Plückthun. He speaks on his quest for modular binding of linear epitopes in pursuit of the assembly of a binding protein from knowing only the sequence of the target. Excelsior, Dr. Plückthun!

Good morning all! Join us same time/same place for the final day of #PEC2022

Hometown hero Mo Nasr presents his work next on designer biosensors as tools for optimizing engineered biosynthetic pathways. Utilising engineered transcription factor biosensors, this work aims to develop robust high-throughput molecule detection tools.

Continuing the morning, Dr. Spencer MacDonald (Spence) presents his work on a novel beta-1,3,-N-acetylglucosaminise phosphorylase. Deemed acholetin phosphorylase, AchP's mechanism provides an efficient way to produce acholetin, a new biodegradable polymer.

Finishing our penultimate session is our 10th keynote by Dr Basil Hubbard (Basil P. Hubbard, PhD). Dr Hubbard highlights the engineering of CRISPR systems through xenonucleic acids. This aims to decrease off-target effects and increase use across SNPs. Thanks for joining us, Dr. Hubbard!

Dr. Evamaria Petersen starts our final session with her work on plastic degradation and novel engineering approaches of serine hydrolases. These methods enable the exploration of functionality beyond the sequence and aims to overcome barriers to these enzymes as plastic degraders

Dr. Donya Valikhani (Donya Valikhani) takes a big picture approach using indigo formation as a predictor of substrate promiscuity in large P450 BM3 libraries. Cost effective and sensitive primary screening aims to simplify the engineering of P450 BM3 for value-added compounds.

Our last keynote, Dr. Huimin Zhao (Huimin Zhao) brings #PEC2022 to a close with a deep dive on directed evolution, showing his work developing a suite of protein engineering tools including the development of an AI-driven robo-protein engineer. Thanks closing us out, Dr. Zhao!