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testing again

Was excited to read what's been happening with #GABAA receptor #ionchannel drug basmisanil these past years (PMID: 33833333). Highlights epic efforts required to get drugs to clinic. Fingers crossed for #schizophrenia trial!

The Miller lab is delighted to announce its first publication! Mechanisms of inhibition and activation of extrasynaptic alpha-beta GABAA receptors. nature.com/articles/s4158…. nature Vikram Kasaragod Dept. of Pharmacology, Univ. Cambridge BiocEM Cambridge and Smart Lab UCL Neuroscience

The neurotoxin alpha-Cobratoxin which causes paralysis by acting on nicotinic acetylcholine receptors is shown here bound to a GABA-A receptor to stabilize the “resting” (closed) state.

The endogenous neuromodulator, zinc, is shown to block the GABA-A receptor pore at a high sensitivity site on the extrasynaptic alpha-beta receptor type.

The receptor is “captured” bound by GABA but with the 9’ activation pore gate closed. This is consistent with the low probability of opening that alpha-beta channels show (versus alpha-beta-gamma channels), a natural means to limit their impact on blocking nerve signalling.

The Miller lab Dept. of Pharmacology, Univ. Cambridge is looking for an enthusiastic postdoc to study antibody modulation of ion channels! A previous relevant publication from our group is nature.com/articles/s4158… Job details 👉 jobs.cam.ac.uk/job/35285 DEADLINE 15th JULY

Don’t like the idea of self-injecting antibodies to treat yourself? Eat them with strawberries instead! Seems too good to be true – incredible! “Strawberry enhancer pelargonidin enables oral protein delivery” Prof. Katie Whitehead pnas.org/doi/epdf/10.10…

The Miller lab Dept. of Pharmacology, Univ. Cambridge is looking for an enthusiastic postdoc to study antibody modulation of ion channels! A previous relevant publication from our group is nature.com/articles/s4158… Job details 👉 jobs.cam.ac.uk/job/37880/ DEADLINE 30th NOVEMBER

Great opportunity here!

Two magnificent opportunities here in Cambridge pharmacology!

Great postdoc opportunities designing antibodies/ligases/proteases for Modular Activator and Silencer Therapeutics (MAST). Mentor support Paul Miller Laura S Itzhaki HowarthSci Hollfelder Lab Catherine Wilson and Sormanni labs! jobs.cam.ac.uk/job/45358/ Dept. of Pharmacology, Univ. Cambridge

Congrats to Paul Miller and Dept. of Pharmacology, Univ. Cambridge protégé, Mr (now Dr!) Ollie King on successful defence of his PhD thesis! Huge thanks to Dr Janet Kumita Janet Kumita and Dr Greta Hultqvist for putting Ollie through his paces!

Exciting postdoc opportunity in Cambridge Protein Screening Facility for binder platform development! Part of great team! Run by Paul Miller Laura S Itzhaki markohyvonen bsky social HowarthSci Hollfelder Lab Catherine Wilson and Sormanni labs! jobs.cam.ac.uk/job/48610/ Dept. of Pharmacology, Univ. Cambridge Cambridge Biochemistry