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Dear friends - many of you reached out with words of solidarity and a question "what can I do?". Here are some (rather simple and straightforward) ways you might want to #StandWithUkraine: 1/4

My eyes have been glued to the TV the past few days watching the unbelievable Russian invasion of Ukraine. I stand with Ukraine 🇺🇦 and the brave and heroic Ukrainian people fighting for the survival of their country. Here’s how you can help: time.com/6151353/how-to…

Want to help Ukraine (and its people or soldiers) financially? Here is a list of six reputable charities and outlets suggested by a colleague of mine in Ukraine -- covering different ways to help (please RT): 1/

Please spread the word – the Balskus Lab is searching for a lab manager to join our team!!! If you are excited to explore the chemistry of the human microbiome together with an amazing group of chemists and biologists, check out this job posting! hhmi.wd1.myworkdayjobs.com/en-US/External…

Check out this awesome perspective by grad student @steph__rob on exciting work by Kevin Ngan, Pallavi Gosavi, Brian Liau, Liau Lab to profile resistance-driving mutations in neosubstrates of molecular glues! Thanks ACS Central Science for the opportunity! pubs.acs.org/doi/10.1021/ac…

Our paper is now online in its final form (CellChemicalBiology)! We show that the isoform and complex selectivity of HDAC inhibitors is governed by dynamic process in cellular contexts (1/2). sciencedirect.com/science/articl…

Have ever wondered it would be useful to have a handy tool for quick mapping and investigation of mutations, together with functional/genomic scores or any protein residue-wise annotation on protein 3D structure? Especially when the mutation is rare and de novo? 1/10

Epigenetic dysregulation is a cancer hallmark. Restoring the benign epigenetic state is effective therapeutically, but what about pushing tumors further into epigenetic dysregulation? Check out our preprint out biorxiv from Liau Lab to learn more! biorxiv.org/content/10.110…

Excited to share our latest work revealing a repressive methylation ceiling in EZH2-mutant lymphoma! We made this discovery by finding drug addiction mutations, a strategy we expect to be broadly useful for uncovering new biology across drug targets. (1/7) biorxiv.org/content/10.110…

Super excited to announce that we’ve just submitted the latest Liau Lab ~manuscript~! Tldr: we used base editors + a methylation reporter to do a mutational scan of DNMT3A, a key cancer gene. Highlights below, but check out our preprint at biorxiv! biorxiv.org/content/10.110…

DNMT3A is 1 of the most highly mutated genes in heme malignancies & clonal hematopoiesis with >250 mutations. Ever wonder what mutations in DNMT3A do to its function?🤔 (1/3)

We can map DNA-DNA contacts to chart 3D genomes with classic Hi-C, but where are these contacts positioned in the nucleus? Proud to release a new flavor of Hi-C, LIMe-Hi-C, a method that tags & maps DNA-DNA contacts relative to the nuclear periphery! (1/N) biorxiv.org/content/10.110…

Activity-based CRISPR Scanning Uncovers Allostery in DNA Methylation Maintenance Machinery biorxiv.org/cgi/content/sh… #bioRxiv

Activity-based CRISPR Scanning Uncovers Allostery in DNA Methylation Maintenance Machinery biorxiv.org/cgi/content/sh… #biorxiv_genomic

keeping the Liau Lab 2022 streak alive w/ another preprint out now tl;dr — we exploit activity-based selection and develop new tools for CRISPR scanning to tackle the difficult task of finding allosteric sites 🧵thread below (1/7): biorxiv.org/content/10.110…

How do you get resistance mutations when a drug nearly carbon copies the substrate? 🤔 By distal, allosteric activation! See how we exploit this chemical subterfuge to systematically search for allostery in DNMT1 & UHRF1 in our latest pre-print. 1/N biorxiv.org/content/10.110…

⁦bioRxiv⁩ from our lab by ⁦College of Chemistry⁩ grad student ⁦Ellie King⁩ & ⁦Novartis Science⁩ on using chemoproteomics to discover a covalent molecular glue degrader targeting NFKB1! Thanks also to ⁦The Mark Foundation for Cancer Research⁩ ! biorxiv.org/content/10.110…

Are you working in TPD/#PROTAC-development and would welcome a simpler, faster, higher throughput way to quantify the abundance of endogenous target proteins directly in cell lysates, while getting a sensitive target engagement assay for ligand characterization for🆓?

Thank you Brian Liau for your mentorship and guidance over the years! I wouldn’t be here without your and Ivan Korendovych mentorship! I enjoyed my time in the Liau Lab taking on new scientific challenges and working with an exceptional group of scientists. Thank you Liau Lab!

Very happy and proud to be able to share my work on the covalent reactivity of functionalized 5-hydroxy-butyrolactams on chemRxiv➡️ doi.org/10.26434/chemr…