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Dr. Chad Pecot's team shows that an EGFR-directed RNAi molecule is highly selective for KRASG12V and exhibits improved therapeutic activity over pan-KRAS targeting, including enhanced inhibition of lung, colon, and pancreatic cancer hallmarks. bit.ly/44p2VcX

What is the impact of natural glycosylation on #islet #amyloid polypeptide aggregation? 🤔 Gain insights from this Science Advances study: bit.ly/3I5Bnk1

Introducing Orforglipron, an oral small-molecule GLP-1 receptor agonist, in early #T2D! 💊 ACHIEVE-1 trial investigators report that in adults with early T2D, orforglipron significantly reduced the glycated hemoglobin level over a period of 40 weeks. NEJM |

Collaborators, including Dr. Trevor Reichman from University Health Network, show that zimislecel, an allogeneic stem cell–derived islet-cell therapy, can restore physiologic #islet function. 🩺 More in NEJM: bit.ly/468Q7bV

⚗️ Guangzhou Medical University scientists summarize the updated understanding of glucose metabolism in mature β and stem cell-derived β (SC-β) cells, highlighting a potential metabolic defect underlying SC-β immaturity. Cell Reports | bit.ly/3T9DJ3R

Dr. nancy papalopulu and team at UoM Biology, Medicine and Health report that NEUROGENIN3 (NGN3) protein expression is oscillatory in human pancreatic endocrine progenitors. Non-oscillatory NGN3 results in earlier differentiation. Developmental Cell | bit.ly/3Giuono

Collaborators review the scientific advances, the clinical trials, and regulatory considerations that will need to be overcome for human stem cell-derived pancreatic islet-like cells to become the next #CellTherapy breakthrough for diabetes treatment. go.nature.com/4nwrVGX

✅ Check out this new Signal Transduction and Targeted Therapy(STTT) article! Scientists elucidate a novel STYK1-driven mechanism for Wnt/β-catenin activation in APC-independent #PancreaticCancer. go.nature.com/4lxyPJV

Stay on top of pancreatic science with curated updates from Pancreatic Cell News by STEMCELL Technologies Science News. Subscribe now! bit.ly/4kkWMEu

Congratulations to Dr. Michael Karin and team on their new Nature Cancer study! 👏 They found that a self-amplifying NRF2–EZH2 epigenetic loop converts KRAS-initiated progenitors to invasive pancreatic cancer. ➰ go.nature.com/4ns7lHD

A sweet connection with a not-so-sweet effect. 🍬 Collaborators examine the complex pathophysiology of #PancreaticCancer-induced #hyperglycemia, focusing on impaired insulin sensitivity, β cell dysfunction, and more. bit.ly/44bBwv5

In this Cell Reports study, scientists showed that increased expression of cingulin (CGN) promoted pancreatic acinar-to-ductal metaplasia and CGN is progressively upregulated during #PDAC initiation and progression. 👉 bit.ly/44LKCPh

.Vanderbilt School of Medicine scientists report that pancreatic islet β-cell subtypes are derived from biochemically-distinct and nutritionally-regulated #islet progenitors. 🧫 🕳️ Dig into the details: go.nature.com/4eSbEZ3

Dr. Esak Lee (Esak (Isaac) Lee) and his team at Cornell University have identified ALK7 inhibition as a promising strategy to target early metastatic dissemination in #PDAC. Read the paper in Molecular Cancer: bit.ly/402v86X

#PDAC ranks among the most aggressive cancers with missense p53 GOF mutations in the TP53 gene being associated with worse clinical outcomes. 🧪 Dr. Shiv K Singh & Lab and his lab at Universitätsmedizin Göttingen (UMG) have untangled misp53 mutants' therapeutic vulnerabilities: bit.ly/462RadG

📣 New target for trametinib-resistant #PDAC identified by Dr. Dongxin Lin & collaborators at Sun Yat-sen University! Check out Gut Journal for the mechanism behind trametinib resistance and learn more about MAX dimerisation protein 1 as a druggable target: bit.ly/44nFOj3

Dr. Bulent Ozpolat's lab at MD Anderson Cancer Center found that eEF2K is associated with shorter patient survival and that eEF2K signaling is critical for #PDAC tumor growth. 🐭 Inhibition of eEF2K successfully suppressed tumor growth in two PDAC mouse models: go.nature.com/4lKudQT

Dr. David Hodson (David Hodson) and team show that GLP1R is enriched as nanodomains on beta cell membranes that contact alpha cells, in keeping with increased single-molecule transcript expression. 💡 Learn more: bit.ly/451mubz

Tick tock ⏰ Explore clock genes in pancreatic disease progression in this new review. 👇 bit.ly/44yGjXM

📢 Check out this new review to know how tumor-stroma crosstalk mechanisms shape metastatic progression in #PDAC! Journal of Clinical Investigation | bit.ly/44SLr83