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DESMOPLASTIC SMALL ROUND CELL TUMOUR. IHC: desmin. NGS: EWSR1::WT1. NB: sheets of polygonal-spindle cells; eosinophilic cytoplasm; monomorphic round-ovoid nuclei; occasional thin collagen bands; ~ one third of cases lack 'conventional' histological features (PMID: 9808123).

🔬 New case report: Rectal malakoplakia identified incidentally in a Crohns patient highlights diagnostic challenges in IBD pathology. This rare finding reminds us to maintain a high index of suspicion and consider malakoplakia in atypical presentations. #PathTwitter #GIpath

I know I've posted about this relatively recently, but this was too pretty to pass over. X10 for orientation, x40 for detail What IHC would be positive in the nuclei?

Let’s review various adenoses of breast this week! Case of Sclerosing Adenosis of Breast 🔬 Sclerosing adenosis shows increase in number of glands (‘adensosis’) distorted by perilobular stromal sclerosis and fibrosis. #PathX #PathTwitter #breastpath

⚡️ SPEP ➡️ SERUM Protein Electrophoresis. 🤯 Serum > 1,500 circulating proteins ⚠️ But NO Fibrinogen. 🤔 If you do Electrophoresis w PLASMA --> Fibrinogen can create a spike and can👀 like M Spike🦴 🧪 You can do IFE to verify, but that’s why you do SPEP not “PPEP”

#GUPath.. Register now for our exciting upcoming 5th talk of this series… 📜MEU India presents… 🧿Dr. Sambit Mohanty Memorial Series in Genitourinary Pathology.. 🗓️ 16th July, 2025: Dr. Andres Martin Acosta will be talking on “Sex cord stromal tumors of the Testis”

NOT a lymph node FNA, this spectacular cell block is from a pleural effusion of a patient with known history of pulmonary tuberculosis. I've rarely if ever seen that many "necrotizing granulomas" in an effusion sample, some with the classic Langhans giant cells.

Pathology routine, or as they say — fear often has big eyes. A tumor like this, seemingly obstructing the lumen of the sigmoid colon and measuring about 5 cm in diameter, turned out to be just a lipoma that had simply pushed the epithelium above it.

🤔 Cancer or Nah, it's not Cancer? #pathx #pathologyx #entpath #dentalpath #ops #headandneck #pathology #pathtwitter

🤔 What is the finding below of terminal ileum? 🤔 What does this patient most likely have? #pathX #gipath #pathology

This has been posted many times before but it is just such a perfect example! Who knows what it is? Breast core needle biopsy #breastpath #pathology #pathresidents #pathx #pathtwitter #pathbugs

Nice example of decoy cell.

Foreign body reaction secondary to calcium hydroxyapatite cosmetic filler material

Cute finding in axillary lymph node biopsy ⬇️ those macropages are full silicone droplets 💦 this is a case of silicone lymphadenitis in a woman with breast implants #CytoPath #PathX #BreastPath #PathTwitter PathologyOutlines.com International Academy Cytology #PathTrainee #ESPAlumni

37 y.o. M. What is your diagnosis based on the gross photo? #PathTwitter Mass General Brigham Pathology MGH Pathology

😮 Very interesting Skin Tumor 🧂 Looks like Merkel. CK20 = perinuclear dot like. Neuroendocrine markers + 🧬 BUT CD99 diffusely membraneous and EWSR1-ERG fusion t(21;22) ---> (Primary) Cutaneous Ewing's! Open Access Article (Moubarak et al) ⬇️ doi.org/10.1111/cup.14…

Prostate cancer diagnosis Lack of basal cells (most sensitive); they have a triangular shape (Hershey kiss) Practical approach to signing out GU pathology cases-Dr. Hirsch #USCAP25 #PathX #pathology

Currently in Army 🪖 basic training —learning a lot outside of pathology but some principles connect. One phrase stood out: "Better to learn it and not need it than to need it and not know it." It reminded me how in pathology, why we learn the rare 🦓 (Views - my own)

It was amazing catching up with Dr. Garder, a featured speaker at FSP Summer Conference, and the person who first got me started on #PathTwitter. #Pathology needs more superstars like him! #pathx ⁦Florida Society of Pathologists⁩ ⁦Jerad Gardner, MD⁩ ⁦Moffitt Cancer Center⁩ ⁦#FLPathConf

🧠 These cells in the brain always confused me because they are big, epithelioid and have prominent nucleoli. 🧠 They are NORMAL though. 🧠 What are they? 🤔 #pathx #pathology #histology #neuropath #medx #usmle