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As an Industry Partner, Complete Genomics will have the opportunity to accelerate CMI’s innovative projects through their next generation sequencing technologies and spatial genomics workflows. cmi.ucsd.edu/2025/01/09/cmi…

Was so great to see you again and your lab members. Also enjoyed talking about bile acid metabolism. I think people will be very excited to see how much they are metabolized by microbes.

An oldie but a goodie 😊 Interested in using the CMMC knowledgebase or contributing your data? Check out this workshop to learn how or see us at cmmc.gnps2.org

Discovery of a family of bile acid-methylcysteamines nature Cornell University @group_Schroeder #activitymetabolomics A nuanced interplay between host and microbiota in regulating bile acid signaling pathways through FXR with a new target for metabolic disorders doi.org/10.1038/s41586…

Great example of metabolites discovered with molecular networking.

New preprint alert!! ClusterApp for #metabolomics is finally here and it is glorious!! biorxiv.org/content/10.110…

It's clear that many do not understand what NIH-funded research does to improve health. It's time to revive a study published 10 years ago that provides incredible information about this. link in the comment Every single new drug approved by the FDA from 2010–2016 was built on

This preprint allows for “explanation” of the ion forms using khipu ore annotation and conclude that the dark matter are mostly real compounds - still dark. They find less than 10% ISFs. In the end ISF prevalence is dependent on instrument tuning, type/amt of analyte, matrix, etc

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Happy to share this preprint from our team, great collaboration with Mikael Knip, Pieter Dorrestein, Lahesmaa Group, and Petter Brodin. Special kudos to Santosh Lamichhane . Trajectories of microbiome-derived bile acids in early life - Insights into the progression to islet

This is a special one for us at Enveda: rooted in what matters most in drug discovery, the promise of your drugs. Let’s go!

Rationally minimizing natural product libraries using mass spectrometry. Interesting work from McCall-Lab and colleagues. Congrats Laura journals.asm.org/doi/10.1128/ms…

A study using an n=1 experiment with single standards at 0V CID reported that 70% of detected ions were in-source fragments (ISFs). nature.com/articles/s42... This was extrapolated to suggest that ISFs affect all experiments to this degree. A counterpoint. rdcu.be/ebFwc

Very important thread from Pieter Dorrestein over on blueksy. #metabolomics bsky.app/profile/pieter…

CORRESPONDENCE | Y El Abiead, Pieter Dorrestein (UC San Diego) et al.: Discovery of metabolites prevails amid in-source fragmentation #massspec nature.com/articles/s4225…

We are back again with the April Molecule of the month featuring Colibactin! Check out more at cmmc.gnps2.org

Thanks to all our lovely collaborators for this accomplishment!

This project was a massive collaborative effort between Duke University , Caltech , and UC San Diego. A big thank you goes to the PIs who made this possible - Rima Kaddurah-Daouk, Sarkis Mazmanian, Rob Knight, and Pieter Dorrestein - and all the collaborators! 13/n