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With both studies now underway at RCH we've made it to double digits - 7 participants recruited to PEAChY-O and 3 to PEAChY-M. Only 686 to go...🍑🤗

With 30 patients recruited to PEAChY-O to date we are nearly 10% of the way there! A big thanks to all the clinicians who has recruited a participant so far. Stay tuned for more updates as we go multi-centre over the coming months.

Thanks to the ACEM CTN for featuring our trials in this months newsletter!

Looking forward to catching up with fellow emergency researchers and providing an update on the progress of the PEAChY studies this week at the ACEM research seminar.

Fabulous first morning at the ACEM Research Network Symposium ARISE Fluids RCT BUCKLED Research PEAChY_RCT FEISTY_RCT

Here is our PhD candidate Elyssia Bourke at the Women's and Children's Hospital Adelaide, undertaking a study site visit with WCH ED research coordinator Gaby. WCH are doing an amazing job at recruiting participants since they started in June - keep up the great work team!

Great news: we have recruited 20% of the required participants for PEAChY-O and as of today GCUH ED Gold Coast Health Emergency Care Research Group have commenced recruitment for both studies meaning 5 sites are up and running! Looking forward to providing all the details at the Team DFTB conference next week.

Thanks to the Team DFTB for the opportunity to present an overview of paediatric behavioural disturbance and an update on the PEAChY trials. We will try our best to keep all of our new followers up to date with the latest on the studies #DFTB22

The ED staff at Monash Children's have been doing an awesome job of enrolling patient's into PEAChY-O&M. Pictured is Monash's PEAChY research lead & ED clinical nurse specialist Kath with PEAChY trial coordinator Kate. Huge thanks also goes to Simon Craig Monash's PI!

Mental Health Emergencies Around the World Event 1pm 27 Oct UTC “We're seeing acutely agitated children in LMIC and HIC countries, the causes and difficulties may differ, but the management remains the same.” Simon Craig Elyssia Bourke PREDICT network bit.ly/3PTckj6

Grateful to be running these trials within the amazing PREDICT network and pleased to share that we have recruited 30% of participants for PEAChY-O and 10% of participants for PEAChY-M to date

Paediatric acute severe behavioural disturbance #OpenAccess doi.org/10.1111/1742-6… Elyssia Bourke Simon Craig PREDICT network Wiley Clinical Health ACEM

It's been a big year for PEAChY. A huge thanks to the investigators, clinicians and participants. We end the year having recruited 50% of the total required for PEAChY-O and 17% for PEAChY-M. Looking forward to a productive & collaborative 2023. Happy New Year from team PEAChY!

The PEAChY studies are off to a great start in 2023! >60% of total recruited to PEAChY-O and >20% recruited to PEAChY-M. Here is Kate the PEAChY research co-ordinator at Gold Coast Health Emergency Care Research Group with Zac from the GCUH ED research team at a recent trial site visit. PREDICT network ACEM

Have you ever wished you could read the nitty gritty details of the PEAChY-O & M trials? Well now you can! Both protocol papers have been published Open Access in BMJ_Open PREDICT network bmjopen.bmj.com/content/13/3/e… (PEAChY-O) bmjopen.bmj.com/content/13/3/e… (PEAChY-M)

Huge thanks to our best recruiting site - the team at Women and Children's Hospital Adelaide ED (featured: Gaby research co-ordinator) we have made it to >80% for PEAChY-O and >30% for M. Well done to all the other sites as well. On the home stretch now for the oral study!

~BREAKING NEWS~ PEAChY-O is finished > 348 participants Thanks to: Prof Franz Babl (CPI), Simon Craig (grant CIA), Kate Klein (trial coordinator), the PIs, RAs, ED clinicians & the participants. Stay tuned for results! PREDICT network (Photo of my little 🍑 for the algorithm)

Results are out! Oral olanzapine & diazepam were equally effective and both appear safe. 40% of patients did not achieve successful sedation. In 15% of cases, healthcare staff were exposed to verbal or physical aggression. More research is required to guide effective therapies.