🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Congrats Pedro Rebelo-Guiomar and rest of the team!

How cool is that? 😎

Enjoying Pedro Rebelo-Guiomar ’s presentation during #EMBOmitochondria2022 in Bro - an in-person (!) conference focussed on mito. gene expression - meetings.embo.org/event/22-mitoc… The Martin Ott lab Nils-Göran Larsson MRC MBU Postdocs MRC MBU

Congratulations to our Baby PhD Student 👶👩‍🎓 😉 Lucía Luengo-Gutiérrez for publishing her MSc work in nature!!! Congrats to digiovannilab, Elisabeth Serger and the team 🎉🥳 👏 nature.com/articles/s4158…

It was indeed a great pleasure to be presenting our recent data in the 3rd The Champ Foundation conference and meet some of the SLSMDS families. Thanks a lot for supporting our research. Minczuk Lab MRC MBU Postdocs

It’s all about having fun… inside and outside the lab 🤩 thanks all!

Please check out our latest The Biochemist mini-review on genetic engineering of the mitochondrial genome | Chris Mutti Pedro Silva-Pinheiro MRC MBU Postdocs MRC MBU Fixing the powerhouse: genetic engineering of mitochondrial DNA portlandpress.com/biochemist/art…

We are looking to appoint a Research Assistant to help our pre-clinical research in collaboration with the MRC MBU start-up Pretzeltx.com - please see below 👇 and RT 🔄 Thanks! mitojobs Cambridge University jobs.cam.ac.uk/job/36565/

Our collaborative work led by Benedict Tan Mito@GU identifies a new promoter (LSP2) in human mitochondrial DNA. We also mutated LSP2 to show it operates in living cells. Congrats to all involved Chris Mutti Pedro Silva-Pinheiro Cambridge Clinical Mitochondrial Research Group @NCL_mtDNA et al. sciencedirect.com/science/articl…

Many thanks to Dorothy Clyde Nature Reviews Genetics for highlighting our collaborative discovery of a new promoter (LSP2) in human mitochondrial DNA #mtDNA. Congrats again: Benedict Tan Mito@GU Chris Mutti Pedro Silva-Pinheiro Cambridge Clinical Mitochondrial Research Group @NCL_mtDNA et al. nature.com/articles/s4157…

Collaboration with David R. Liu led to compact mtDNA base editors (ZF-DdCBEs) for improved in vivo applications. The small size of ZF-DdCBEs allows for a single AAV delivery and efficient (up to 60%) editing in multiple tissues Pedro Silva-Pinheiro Nature Communications nature.com/articles/s4146…

This work was a terrific collaboration with Pedro Silva-Pinheiro & Minczuk Lab. Congratulations to Julian Willis (on the academic job market), Pedro, Lily Widdup (@ChemIsTry2351), and Michal Minczuk. See also related work from Jin-Soo Kim's lab (Ref. 29). 8/8 nature.com/articles/s4146…

Today Pedro Silva-Pinheiro etal. present in Nature Biomedical Engineering a library of base editors #MitoKO to ablate all protein-coding genes in mouse mtDNA. #MitoKO will help generating new, clinically meaningful models for mechanistic, drug discovery and pre-clinical studies nature.com/articles/s4155… 1/8

A huge thanks to Xin Lou, Bin Shen & Nature Biomedical Engineering for the News & Views highlight of our recent work on mtDNA base editors (DdCBEs) to knock out each mitochondrial protein-coding gene in cells & mice #MitoKO (Full paper here: nature.com/articles/s4155…) nature.com/articles/s4155…

Please have a look into our contribution to the Mitochondrial DNA - Methods and Protocols book: link.springer.com/protocol/10.10… Thanks a lot for inviting us @NCL_mtDNA and Mito@GU!

Delighted to have given the opening lecture at MitoPorto2023 this morning. Great meeting and hospitality organised by Jorge Oliveira sites.google.com/view/mitoporto…

Looking forward to this one!

Busy few days for Minczuk Lab at #Euromit2023: Pedro Silva-Pinheiro gave a talk on #MitoKO, Lucía Luengo-Gutiérrez presented a poster on retinal pathology in mtDNA mouse model & Michal gave an overview on mtDNA editing activities in the lab. (The party was fantastic too) MRC MBU MRC MBU Postdocs

(1/2) Meet our Horizons speaker, Dr. Michal Minczuk! Dr. Minczuk is an MRC Investigator at the MRC Mitochondrial Biology Unit, University of Cambridge MRC MBU Cambridge University. His research focuses on understanding the regulation and expression of the mitochondrial genome.

It's always nice to see old mito-friends ! Carlo Viscomi Minczuk Lab