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Our new paper “Hypoxia-driven protease legumain promotes immunosuppression in glioblastoma” is out in Cell Reports Medicine. This is a team effort and includes three co-first authors Lizhi, Songlin and Fatima. Thanks so much for reviewers and editor. cell.com/action/showPdf…

Thank you so much Justin Lathia, PhD 🧠🕺🏽 Defne Bayik Bruno Colon and Jonathan for this excellent preview on our work published in Cell Reports Medicine.

Our manuscript focusing on LDHA-regulated tumor-macrophage symbiosis in glioblastoma is finally out Nature Communications. nature.com/articles/s4146… Thanks all editors and reviewers.

Please check our review regarding epigenetic-regulated tumor-immune interactions in glioma. Thanks to all authors, reviewers and the editor from Trends in Molecular Medicine

Findings from Lurie Cancer Center's Peiwen Chen and collaborators suggest that a metabolism-related gene, LDHA, could serve as a potential therapeutic target for #glioblastoma, according to a recent study in Nature Communications. news.feinberg.northwestern.edu/2024/03/26/inv… via Northwestern Feinberg School of Medicine #BTSM

Thanks Trends in Molecular Medicine and the editor Dr. Aliki Perdikari for highlighting our review regarding epigenetic-regulated tumor-immune symbiosis in glioma on the May issue cover! cell.com/trends/molecul…

Thank you Journal of Clinical Investigation for this opportunity to write this review focusing on epigenetic regulation of tumor immunity.

We finally had a chance to get together for a lunch after our move to Cleveland Clinic Lerner Research Institute in July.

Thanks Cancer Research for this opportunity to write the commentary highlighting a fantastic paper from Cell “Macrophage-mediated myelin recycling fuels brain cancer malignancy” by Dr. Leila Akkari and colleagues. aacrjournals.org/cancerres/arti…

Excited to share our paper just accepted by Journal of Clinical Investigation. We reveal a new macrophage-microglia interplay in GBM and develop a powerful therapeutic approach targeting them. jci.org/articles/view/…

Lipid-laden #macrophages recycle #myelin to feed #glioblastoma—this In the Spotlight commentary by Peiwen Chen and colleagues highlights a recent Cell paper by Leila Akkari et al. bit.ly/3zNHPZs

Excited to share our review: “Immunotherapy for GBM: current state, challenges, and future perspectives ", just published in @Cellular & Molecular Immunology rdcu.be/dW19V

Read the In The Spotlight commentary "Lipid-laden macrophages recycle myelin to feed glioblastoma:" bit.ly/3Ogkovn By Peiwen Chen and colleagues discussing a recent Cell paper by @LeileAkkari1 et al.

Check out our review article: Protease Regulation of Tumor-Immune Cell Symbiosis, just online Trends in Cancer, huge thanks the editor for this opportunity. kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F%2…

Happy to share our work out at Journal of Clinical Investigation We identified a new tumor-macrophage interaction contributing to GBM progression/immunosuppression and found that targeting the symbiosis sensitizes GBM to immunotherapy. Huge thanks to editors and reviewers. jci.org/articles/view/…

Ride for cure brain cancers. Thanks for considering donation via this link: give.velosano.org/fundraiser/638…

Improving immunotherapy in glioblastoma! Peiwen Chen & team Cleveland Clinic discover targeting legumain—which promotes infiltration of tumor-associated macrophages via the GSK3β/STAT3 pathway—has anti-tumor effects and improves immunotherapy in preclinical GBM models:

Our work focusing GPNMB -mediated GSC-TAM symbiosis is out JCI insight insight.jci.org/articles/view/… Thanks to all authors, editors and reviewers.

Disrupting cell communication in glioblastoma— Peiwen Chen and team Cleveland Clinic discover GPNMB mediates bidirectional communication between GBM stem cells and tumor-associated macrophages and microglia: insight.jci.org/articles/view/…

Grateful and honored to receive the CLIP award from Cancer Research Institute . This support will enable us to investigate the biology of MDSCs, and to develop novel immunotherapies targeting these cells in glioblastoma. Thank you to CRI for supporting our work—excited for what’s ahead!