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Cell-death induced immune response and coagulopathy promote cachexia in Drosophila. Ankita Singh, Yanhui Hu, Raphael Fragoso Lopes, Liz Lane, Hilina Woldemichael, Charles Xu, Namrata D. Udeshi, Steven A. Carr, Norbert Perrimon doi: doi.org/10.1101/2025.0…

events.cancer.gov/dcb/beyond-mam… Virtual seminar series that the US National Cancer Institute (NCI) is holding on non-mammalian models of cancer.

The epigenetic factor Zrf1 regulates intestinal stem cell proliferation during midgut regeneration Joshua Shin Shun Li, Liu, Kim, Qadiri, Xu, Xia, Binari, Asara, Hu, Perrimon bioRxiv 2025.01.16.633419; doi: doi.org/10.1101/2025.0…

TF2TG: an online resource mining the potential gene targets of transcription factors in Drosophila. Hu, Rodiger, Liu, Gao, Liu, Qadiri, Veal, Bulyk, Perrimon biorxiv.org/content/10.110…

Simonian, Meyer, Guo, Sha, Wohlschlegel, Droujinine, Perrimon, McMahon (2025) Sex and depot specific adipocyte proteome profiling in vivo via intracellular proximity labeling. Comprehensive Physiology. 15(2):e70007. doi: 10.1002/cph4.70007. PMID: 40181252

Lipid metabolism of hepatocyte-like cells supports intestinal tumor growth by promoting tracheogenesis Kerui Huang, Ting Miao, Ezequiel Dantas, Myeonghoon Han, Yanhui Hu, Keven Wang, Jack Sanford, Marcus Goncalves, Norbert Perrimon doi: doi.org/10.1101/2025.0…

Hepatic gluconeogenesis and PDK3 upregulation drive cancer cachexia in flies and mice. Liu, Dantas, Ferrer, Miao, Qadiri, Liu, Comjean , Davidson, Perrier, Ahmed, Hu, Goncalves, Janowitz, Perrimon. Nat Metab. 2025 doi: 10.1038/s42255-025-01265-2. PMID: 40275022

TF2TG: an online resource mining the potential gene targets of transcription factors in Drosophila. Hu Y, Rodiger J, Liu Y, Gao C, Liu Y, Qadiri M, Veal A, Bulyk ML, Perrimon N. Genetics. 2025 doi: 10.1093/genetics/iyaf082. PMID: 40314147

Xiao, G. et al. (2025). Intratumor HIF-1a modulates production of a cachectic ligand to cause host wasting. Cell Insight. doi: 10.1016/j.cellin.2025.100247. PMID: 40336592

Kang et al. (2025) NF-κB-mediated developmental delay extends lifespan in Drosophila PNAS. 122(19):e2420811122. doi: 10.1073/pnas.2420811122.

FlyBase funding thetransmitter.org/community/flyb…

Protein folding stress transcriptionally reprograms muscle metabolism Jacob Paiano, Mujeeb Qadiri, Suhasini Sharma, Yanhui Hu, Norbert Perrimon doi: doi.org/10.1101/2025.0…

masslive.com/news/2025/06/w…

New paper: Ben Ewen-Campen, Weihang Chen, Sudhir Gopal Tattikota, Ying Liu, Yanhui Hu, Norbert PerrimonThe Drosophila proventriculus lacks stem cells but compensates for age-related cell loss via endoreplication-mediated cell growth doi: doi.org/10.1101/2025.0…

New paper: Cholinergic Signaling Modulates Intestinal Pathophysiology in a Drosophila Model of Cystic Fibrosis Elizabeth Lane, Afroditi Petsakou, Ying Liu, Weihang Chen, Mujeeb Qadiri, Yanhui Hu, Norbert Perrimon doi: doi.org/10.1101/2025.0…

New paper: Multi-omic mapping of Drosophila protein secretomes reveals tissue-specific origins and inter-organ trafficking Bosch et al. doi: doi.org/10.1101/2025.0…

New Paper: Viswanatha , Entwisle, Hu, Kim, Reap, Butnaru, Qadiri, Mohr, Perrimon. Higher resolution pooled genome-wide CRISPR knockout screening in Drosophila cells using integration and anti-CRISPR (IntAC) Nature Communications doi.org/10.1038/s41467…

New paper: Song, Y., Hu, Y., Dow, J., Perrimon, N. and Papatheodorou, I. (2025) ScGOclust: leveraging gene ontology to find functionally analogous cell types between distant species. Bioinformatics. 4:i571-i579. doi: 10.1093/bioinformatics/btaf195. PMID: 40662793

Qadiri, e (2025) FlyPhoneDB2: A Computational framework for analyzing cell-cell communication in Drosophila scRNA-seq data integrating AlphaFold-Multimer predictions. Comput Struct Biotechnol J. 27:2814-2822. doi: 10.1016/j.csbj.2025.06.032.