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A new study by Juan Burrone Lab and Dr Lieberam has identified the axon initial segment as the region driving abnormal regulation of neuronal activity in Amyotrophic Lateral Sclerosis Read more🔗 👇 buff.ly/3R0lQmr #KingsIoPPN #IoPPNNews

Feeling incredibly proud today! 🌟 Chris Lambert in my lab just passed his PhD viva with flying colors. A true testament to resilience and perseverance. Congratulations, Dr. Lambert!👏🧑‍💻😊🎉 School of Basic & Medical Biosciences CGTRM KCL MRC DTP

This work was led by Sam Bryce-Smith and a joint effort with Maria Secrier and many others. Parallel efforts from the Gitler and La Spada labs also identify the link between TDP-43 and 3'UTR changes and out now: biorxiv.org/content/10.110… biorxiv.org/content/10.110…

Do you love #RNA and #neuroscience? Are you looking for a #postdocposition on #ALS and gene therapy? Join Ruepp Lab UK Dementia Research Institute Institute of Psychiatry, Psychology & Neuroscience and FrattaLab UCL Queen Square Institute of Neurology for a collaborative pre-clinical project on a novel gene therapy approach for ALS. More info here: tinyurl.com/2cpcbsp3

Delighted to see our study led by Carmelo Milioto revealing a neuroprotective ECM signature in C9FTD/ALS published! Thanks to MND Association UK Dementia Research Institute and many others! nature.com/articles/s4159…

🚨 JOB CALL!!! 🚨 If you’re interested in neuronal cell biology, come and work with us to use custom imaging and omics tools to study organelle contact sites in neurons. Please RT friends‼️ Open calls for a Wellcome funded Post doc and RA position listed below…

We're looking for someone with a creative mindset and excellent modern molecular biology skills (DNA manipulation, Illumina, Nanopore etc) to join our team at UCL and The Crick in the FrattaLab developing candidate gene therapies for ALS. Apply here: jobs.ac.uk/job/DGJ551/res…

So excited that this year's tickets for the Pint of Science are on sale. Come to the George and hear from Errin Roy and Laura Pellegrini on growing brain organoids, Robert Hindges and Аnа Dorrego Rivas on how we see and hear and finally Pete Harley on neurodegeneration. #pint24

Excitatory and inhibitory synapses form a tight subcellular balance along dendrites that decorrelates over development biorxiv.org/cgi/content/sh… #biorxiv_neursci

Thanks to Sarah Marzi and Pete Harley for two fantastic talks on neurodegeneration for our final #pint24 event!

After 18 seasons home and away, this is me checking out of Leeds United. It's been barry™️. And the pleasure's been all mine. As a final piece, I wrote about what all that time and all those games taught me about LUFC. Never change. nytimes.com/athletic/55421…

Thrilled to see this work published! Led by the amazing sally, we show a tight correlation in E and I along dendrites during circuit wiring. Check it out! Guilherme Neves Vincenzo Mastrolia Rachel Jackson Wellcome Biotechnology and Biological Sciences Research CDN | King's College CNDD| King's College Institute of Psychiatry, Psychology & Neuroscience doi.org/10.1016/j.celr…

Happy to share our latest preprint showing that TDP-43 pathology drives extreme, but reversible changes in neuronal excitability in vivo. Proud of the team for these challenging experiments, esp. Tanja Djukic, Zhenxiang and Lasse Jørgensen. biorxiv.org/content/10.110…

We find TDP-43 loss to cause presynaptic defects, which are rescued by ASOs correcting a single cryptic exon in UNC13A. Surprising effect of just one cryptic exon and promising strategy for ALS! Matt Keuss Pete Harley in great collaboration with Juan Burrone Lab biorxiv.org/content/10.110…

We just dropped in on Liz Truss’s pro-Trump speaking tour with a remote-controlled lettuce banner. She didn’t find it funny. 🥬

🚨PhD position alert🕵️ We are looking for a motivated PhD candidate to join our laboratory in Tenerife, Spain, with a 4 year fully funded PhD contract (FPI) associated with a project focussing on understanding the role of TDP-43 in amyotrophic lateral sclerosis (ALS).

Our paper on cryptic splicing-controlled protein expression, which we hope will inspire safer and more adventurous gene therapy approaches for ALS and FTD, has been published in Science Magazine science.org/doi/10.1126/sc…

Tofersen is an effective new treatment for those with the SOD1 genetic variant of motor neurone disease. It works. It can slow progression of their #MND. Join the community and call for NICE to make an exception to its normal criteria. Sign our petition below. #PrescribeLife

Happy to see my Marie Skłodowska-Curie Actions project with Juan Burrone Lab lab available on bioRxiv Neuroscience We Increased network activity in vivo and used dSTORM to look at the nanoscale organization of inhibitory synapses formed onto the AIS and onto tufts dendrites of L2/3 S1 Cortex!