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Our study on how the human MCM2-7 helicase is loaded onto replication origins 🧬 is now online nature! 🎉 Our findings reveal that unlike in yeast, human MCM loading does not require ORC6 and can occur through multiple pathways. Read more here: rdcu.be/d1F6S

We did this crazy project where we tried to see if proteins could interact with their mirror image ligand. Seems impossible when proteins need to form 3D structures to interact. But what about if the interaction remains disordered??? nature.com/articles/s4158…

Excited to share our discovery: CRL4-DCAF12 regulates DNA replication by ensuring proper nascent MCM2-7 complex assembly. This prevents genome instability and diseases like cancer.🙏Big thanks to Hana Sedlackova for the great collaboration! biorxiv.org/content/10.110…

Please RT #GordonConference on "Histone and DNA Modifications" #epigenetics #chromatin 20-25. July 2025. Il Ciocco, Italy. Great speaker lineup. ➡️Register now grc.org/histone-and-dn… Cheryl Arrowsmith Altos Labs Zymo Research New England Biolabs Fox Chase Cancer Center Van Andel Institute (VAI)

New pre-print alert 🚨 Interested in what Ioannis Kafetzopoulos learned about DNA hypomethylation in cancer from investigating surprising gains DNA methylation in DNMT1 KO cells? Read all about it here: biorxiv.org/content/10.110… For a quick summary see this 🧵 1/8 #epigenetics

Our collaboration with the Muir lab revealed that N-terminal histone modifications can 'detoxify' K27M inhibition by altering PRC2-substrate interactions. Acetylation showed the greatest impact, supported by xenograft data from the Monje group. pubs.acs.org/doi/epdf/10.10…

#SIRT7 is a histone deacetylase with highly specific activity on #chromatin substrates. We just published mechanism-based #cryoEM structures of #SIRT7 on nucleosomes to understand its activity 👇 nature.com/articles/s4146… (1/8) #ChemBio

This has been an enlightening project! Cheuk-Ting Law developed TiMEstamp to sift through multiple sequence alignments and discover unusual LINE-1 insertions. Our genome has trapped really cool retroelement recombinations that inform our understanding of transposon evolution. 🧬

Last year, $9B of the $35B that the National Institutes of Health (NIH) granted for research was used for administrative overhead, what is known as “indirect costs.” Today, NIH lowered the maximum indirect cost rate research institutions can charge the government to 15%, above

Extremely clever new NGS tech from Roche 🧬 If it's hard to discriminate between nucleic acids accurately with a nanopore, why not synthesize a new polymer off a DNA template that is easier to sequence? It's an intuitively simple idea, but took *a ton* of creative nucleic acid

The NIH website and related platforms like PubMed are currently down. Has anyone heard any updates on what’s going on or when they might be back online?

The first cancer-related story from our group Weill Cornell Medicine is now published in Molecular Cell. We investigate the role of hyperconnected 3D regulatory hubs in controlling oncogenic programs and properties in glioblastoma and also across 16 cancer types. cell.com/molecular-cell…

Happy Polycomb Day (3/27)! Today we celebrate H3K27me3- Polycomb’s quiet mark of repression, where gene silencing is not neglect, but a deliberate act of identity.