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Happy to share our updated opinion on the physiological roles of BRCA1 in this new review: authors.elsevier.com/a/1lDKu3QxxSyl…

🚨🚨Paper out! 🚨🚨 Delighted to share our work, now published in Nature Genetics 🧬! shorturl.at/94s5S We identified a targetable, chromothripsis-associated genetic event in blast phase (BP) MPN, a particularly poor prognostic subtype of acute leukaemia. 1/n 🧵👇

If tumour genome evolution is deterministic, can we forecast genomic changes? Yes we can! At least for oncogene amps and tumour suppressor dels. Barbara Hernando Ángel Fernández Sanromán present our method for forecasting driver gene copy number change. Preprint: bit.ly/4kxF14y ⬇️1/

Excited to share our new study in Cell—congrats to Daniel, co-authors, and our collaborators in the Peter Ly What began as pure curiosity led to a tool for modulating mitochondrial abundance in vitro and in vivo. A new direction for the Wu lab begins! cell.com/cell/fulltext/…

Targeting DNA damage in ageing: towards supercharging DNA repair nature.com/articles/s4157… This new Review discusses approaches to pharmacologically mitigate the adverse effects of DNA damage to prevent mutation-driven cancers and mitigate age-related degenerative diseases

Really excited to share our new study, where we identified ZNF280A, a novel regulator of homologous recombination during DNA repair, linked to the human 22q11.2 distal deletion syndrome. A special shout out to Thomas Clarke for leading the project! nature.com/articles/s4155…

Endogenous tagging of BLM and PICH reveal their dynamic localization and functions throughout the cell cycle. New preprint: Mitotic BLM functions are required to maintain genomic stability biorxiv.org/content/10.110…

Genomic analyses of mother–father–fetus trios after early pregnancy loss uncover contributions from chromosomal abnormalities and subtle genetic variants go.nature.com/4l849Pj

Just out! Aneuploidy alters cellular proteome and affects many functions. One protein, p62/ SQSTM1, becomes highly abundant and creates cytosolic bodies in cells with extra chromosomes. nature.com/articles/s4146…

3 postdoctoral positions (1 comp, 2 experimental) available @ BaslanLab/Penn. We employ computation & functional biology to develop novel therapeutics, diagnostics & prognostic markers. Further detail below. Please share w/ trainees, colleagues & friends. nature.com/naturecareers/…

1/7 I am very excited to announce our🌹NEW PAPER OUT IN NATURE!🌹 Bimodal centromeres in pentaploid dogroses shed light on their unique meiosis With the Ritz and Kovařík labs we shed light on Rosa canina’s bizarre reproduction! nature.com/articles/s4158… #Meiosis4eva #Centromere

Happy to share that our recent work on the role of USP37 in counteracting the ubiquitylation and premature disassembly of stressed replisomes by TRAIP is now out. A fantastic collaboration with Olga Kochenova in Johannes Walter,Grant Stewart,Steve Jackson Lab nature.com/articles/s4146…

WE ARE HIRING: Postdoc Positions! Join us at UPenn in vibrant Philly, cutting-edge science, great city, amazing team. Please share and let's get in touch!

🚨Chemo treatment upgrade!🚨 Check out our approach to modernise chemotherapy treatment published today in Nature Genetics. From CNIO Stop Cancer Tailor Bio Cancer Research UK nature.com/articles/s4158… More details 👇

Want to better understand nuclear and genome organisation in various organisms, tissues, and cell states? Join Karim Mekhail , altmeyerlab & Irene Chiolo at the upcoming 2nd Spatial Genome Organisation Conference this October! Talk Submission has been extended until 14th July,

Wishing farewell to the first member of our lab, Qing Hu, as she embarks on a new adventure in the Laboratory Genetics and Genomics fellowship program at UCLA. Good luck Qing!

It's 102°F/39°C in New Haven—but 30 international experts have braved the heatwave to join us at Yale School of Medicine for a 3-day workshop on chromosomal instability in cancer. Thank you to our workshop organizers, Roel Verhaak, Florian Markowetz, & Aurelie Ernst!

Delighted to share our latest work showing how cells that evade #senescence after CDK4/6 inhibition are primed to become aneuploid because of their increased size. Great work by super PhD student Aanchal Pareri biorxiv.org/content/10.110…

🚨 Hot off the press!!! Wanted to share this to celebrate the momentous achievement from the Giunta Lab and for the human centromere / genomics communities as a whole... more posts to come next week but for now, happy Fourth & happy reading ❤️🧬💻 science.org/doi/10.1126/sc…

A transcription balance required for genome stability 🧬⚖️ Our work on RNA Pol II transcription speed control by the DNA helicase RECQL5 and the transcription-coupled DNA repair complex is now on ⁦⁦NatureStructMolBiol⁩ #CryoEM #transcription nature.com/articles/s4159…