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Check out our newest work by Peter Bor-Chian Lin in Alz and Dementia Alzheimer's Association where we found reduced Inpp5d attenuates disease pathogenesis. Andy Tsai Shweta Puntambekar Miguel Moutinho @btlamb alz-journals.onlinelibrary.wiley.com/doi/full/10.10…

Congrats to Adrian Oblak and the @NeurosciStark crew on the fantastic study. INPP5D deficiency attenuates amyloid pathology in a mouse model of Alzheimer's disease alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…

Congratulations to the team led by Adrian Oblak! As a follow up of our 2021 paper (sciencedirect.com/science/articl…), Peter Bor-Chian Lin found that INPP5D haplodeficiency perturbs microglial signaling pathways, regulating phagocytosis and amyloid plaques clearance (alz-journals.onlinelibrary.wiley.com/doi/full/10.10…).

Indiana University School of Medicine researchers Adrian Oblak Peter Bor-Chian Lin are studying how the reduction of a gene variant found in the brain’s immune cells could diminish the risk of late-onset Alzheimer’s disease. neurosciencenews.com/alzheimers-gen…

Want to hear about Tau seeding, Genetic Diversity, and Transcriptomic signatures?? ALLFTD Alzheimer's Association The Rainwater Charitable Foundation Check out our bioRxiv below⬇️⬇️⬇️

ApoE isoform– and microbiota-dependent progression of neurodegeneration in a mouse model of tauopathy science.org/doi/10.1126/sc… A delayed tweet. Congrats to Dong-oh Seo and all our great collaborators in this interesting and comprehensive work.

Excited to share our new study about how TREM2 splice isoforms can contribute to a pool of heterogenous sTREM2 and affect synaptic plasticity. Shweta Puntambekar Andy Tsai Israel Coronel Lasagna-Reeves Lab @BradyAtwood Pablo Martínez C. Kwangsik T. Nho @btlamb genomemedicine.biomedcentral.com/articles/10.11…

Feel free to join us and discuss about our latest research on INPP5D study!

I have been working with Andy for years and always motivated by his enthusiasm in science. Great opportunity to work with him and one of the best lab in the field of aging in Stanford！

Here’s the zoom link to my presentation😁 iu.zoom.us/j/85102466890?…

I'm looking for a research professional 1 to work with me on microglia, lipidome, or aging clock. Please feel free to contact me! So many opportunities and projects in the Wyss-Coray lab (web.stanford.edu/group/twclab/c…)! Link for this job: careersearch.stanford.edu/jobs/life-scie…

Very excited to share that my first first-author paper with Jungsu Kim was published this morning in Journal of Experimental Medicine 😄 Thank you to all the lab members, collaborators, and everyone who made this possible!

Amyloid pathology dysregulates proteostasis by reducing ELP3 expression and tRNA modification levels! Congratulations to the team ARS_Lab (tRNA epitranscriptome and Disease) Marisa Pereira!

Congratulations to Andy Tsai for his amazing findings on how the AD risk and protective variants on PLCG2 shifts microglial phenotypes and regulates the amyloid pathology. cell.com/immunity/fullt…

Excited to share our work published in Immunity! We validated the human genetic findings that loss- and gain-of-function PLCG2 variants have opposite effects on transcriptional mechanisms, altering microglial phenotypes and AD pathology in mouse models. cell.com/immunity/fullt…

Check out the latest from MODEL-AD alzforum.org/news/research-…

Our new study! 🚀 With Doug Henze, we uncover region-specific adaptations in cerebellar microglia and provide detailed molecular and spatial data on age-related glial changes in the cerebellum. 🧠 #Microglia A Tony Wyss-Coray & Stephen Quake labs collaboration! biorxiv.org/content/10.110…

Another Tony Wyss-Coray & Stephen Quake labs collaboration! 🔬 With Doug Henze, we identify a subtype of disease-associated microglia with a ramified morphology, challenging conventional assumptions between cellular morphology and microglial states.🧠#Microglia biorxiv.org/content/10.110…

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