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Hi, I’m Petra, a PhD student in infection biology at the Sellin Lab. In my project, I’m modeling enterobacterial infection in organoid-based model systems. I’m looking forward to sharing more about my research next week at #scicommUU21!

Using live-microscopy, I can follow individual bacteria during infection and observe the different steps of their infection cycle in real time. To get a short intro about our group’s research, check out this movie: youtube.com/watch?v=ciL2yH… #scicommUU21

Small intestinal organoids, also called enteroids, are composed of a single layer of polarized epithelial cells surrounding a central lumen. As such, they recapitulate the 3D architecture of the intestine and offer a physiologically relevant model system. #scicommUU21

Why care about enteroids? Because they combine physiology and primary cell behavior of in vivo models with the high temporal and spatial resolution of cell line-based models. Not convinced yet? They are also a unique opportunity for the replacement of animal models! #scicommuu21

During my PhD Sellin Lab, I have familiarized myself with the beauty (and the technical challenges) of enteroid microinjection and applied the model to study the epithelial infection cycle of #Salmonella. Curious? Read the paper here: journals.asm.org/doi/10.1128/mB… #scicommUU21

The enteroid microinjection model with its enclosed lumen, combined with the micorscopy setup Sellin Lab, allows me to follow #Salmonella colonization of the luminal and epithelial niches in real time. For more amazing microscopy 👉🏻journals.asm.org/doi/10.1128/mB… #scicommUU21

Using the enteroid microinjection model, we found that #Salmonella exploits cycles of epithelial invasion and infected cell expulsion to boost luminal colonization. How did we do it? Sellin Lab's paper will tell you! journals.asm.org/doi/10.1128/mB… #scicommUU21

Many people out there have no clue what a researcher is doing (survey by Vetenskap & Allmänhet (Public & Science Sweden)). #scicomm is relevant – and it’s fun! Thanks Eva Garmendia & Hugo Gutiérrez de Terán for an amazing course #SciCommUU21, and Germán Orizaola for curing my anxiety of using #SocialMedia for science communication!