Better together? 🆕💫Large multi-hospital cohort Brent Footer Implementation of a blended vanco dosing approach* with a majority of AUC-based dosing resulted in a statistically & clinically significant reduction in cumulative vanco dose & risk of AKI accpjournals.onlinelibrary.wiley.com/doi/abs/10.100…

Although cysC may be useful in hospitalized patients, the use of cysC to calculate drug dosing in critically ill patients has been incompletely investigated. OPEN ACCESS: buff.ly/lanfJfW

To meet the goal of ending the HIV epidemic, optimized use of the drugs routinely used for treatment and prevention is necessary and DBS monitoring represents a potential way to increase the likelihood of meeting this ambitious goal. buff.ly/9QZpOUc

This emerging evidence supports the utility of GLP-1 RAs as a potential disease-modifying option for OA, offering a dual benefit in metabolic and joint health. buff.ly/jryH9PL

Is there a significant change in potassium levels with sodium-glucose co-transporter-2 (SGLT2) inhibitor therapy in people with type 2 diabetes (T2D)? buff.ly/q8lgd6Q

Although GLP-1RAs are generally not associated with drug–drug interactions via drug metabolism or transporter pathways, their effects on reduced gastrointestinal motility could influence the pharmacokinetics of coadministered oral medications. OPEN ACCESS: buff.ly/ZeDOZVH

Although GLP-1RAs are generally not associated with drug–drug interactions via drug metabolism or transporter pathways, their effects on reduced gastrointestinal motility could influence the pharmacokinetics of coadministered oral medications. OPEN ACCESS: buff.ly/XFTam1S

Utilizing serum clozapine levels may be helpful in guiding dose changes during antipsychotic cross-titration, especially when multiple drug interactions are involved. buff.ly/k08qKYk

Results from this study support the need to create medication management programs to decrease exposure to potentially inappropriate prescribed medications. OPEN ACCESS: buff.ly/bnPaRj7

The concurrent use of thiazide diuretics and SSRIs is associated with an increased risk of hyponatremia in older populations. OPEN ACCESS: buff.ly/e9NKcTG

✨ #CPPPLU Highlights: This systematic review from Pharmacotherapy found when patients received IV thrombolytics while on DOACs there was no difference in in-hospital mortality compared to those not receiving DOACs (OR 0.94, 95% CI [0.44-2]). loom.ly/OxcMDkE #PharmICU

The primary focus of this review is on newly approved antibiotics, along with any additional published evidence on previously reviewed antibiotics. OPEN ACCESS: buff.ly/O9uFmoq

‼️♻️𝗦𝗲𝗴𝘂𝗿𝗶𝗱𝗮𝗱 𝗱𝗲 𝗮𝗻𝘁𝗶𝗯𝗶𝗼́𝘁𝗶𝗰𝗼𝘀 𝗱𝘂𝗿𝗮𝗻𝘁𝗲 𝗲𝗹 𝗲𝗺𝗯𝗮𝗿𝗮𝘇𝗼🤰🏻 Pharmacotherapy 👇🏼👇🏼👇🏼👇🏼👇🏼 📑🔗🔑🔓 t.me/ClubCrit

The median insulin dose reduced from 101 units at baseline to 71 units after 6 months, with a median decrease of 9.5 units (p < 0.001). buff.ly/5OODLAW

In this large multi-hospital cohort, the implementation of a blended dosing method using a majority of AUC-based dosing reduced cumulative vancomycin doses, serum levels, and AKI. buff.ly/nYIqxWd

Surprising turn: Korean cohort study backs #dapagliflozin for kidney safety—contrary to FDA's caution! 🇰🇷 Nationwide data shows 34% reduced #AKI risk with dapagliflozin vs. sitagliptin. Published: Pharmacotherapy #Diabetes #Research #Nephrology #Pharmacy accpjournals.onlinelibrary.wiley.com/doi/full/10.10…

These studies describe a substantial and growing body of evidence focused on improving the management of CKD beyond renin-angiotensin system inhibitors, such as angiotensin-converting enzyme inhibitors & angiotensin receptor blockers. buff.ly/Lp6Olvh

This themed issue aims to disseminate new knowledge on the unique challenges of pharmacotherapy facing clinicians and their female patients in the realm of oncology. buff.ly/sGEZq8d

PK modeling successfully standardized ARV CSF concentrations to a given time point (i.e., CMAX or CTrough) to allow estimation of CSF penetration. buff.ly/KGpDxbJ

Contrary to the United States Food and Drug Administration's safety warning, our findings suggest that dapagliflozin may have a protective effect against AKI in patients with T2DM. OPEN ACCESS: buff.ly/CdHsc8y