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Nice news story about our recent research into the mythical RNA world, where we have explored the structure of the (proposed) central player: the RNA replicase. Thanks to Emil Kristoffersen, Ewan McRae, Phil Holliger and coauthors for making the research possible. sciencenews.dk/en/rna-researc…

@MRC_LMB under Northern Lights #NorthernLights #AuroraBorealis #Cambridge Postdocs of Cambridge (PdOC)

Winner of the 2024 Researcher of the Year category sponsored by AstraZeneca at #SciTechAwards is Dr Benjamin Porebski of @MRC_LMB for developing a method that has the potential to transform the discovery of new medicines

We have submitted our second paper on the topic the RNA world in collaboration with Phil Holliger based on experimental work by Emil Kristoffersen and Ewan McRae in the Andersen Lab. Preprint is available on bioRxiv! Here comes a short explanation of the background and content.🧵1/7:

We are excited to share new mechanistic insights into DNA replication fidelity! How does human DNA Polymerase Epsilon recognise and proofread errors made during synthesis? 🧬 Read NatureStructMolBiol nature.com/articles/s4159…

Sunlit @MRC_LMB this morning.

So fun to be back @MRC_LMB for a visit to Phil Holliger and PNAC. Honored to give a talk in the Sanger Seminar Room!

I've started visiting Phil Holliger lab at @MRC_LMB this week - its been inspiring and challenging in the best way! A short journey from JJ Thomson Avenue (electrons) to Francis Crick Avenue (nucleic acids) :)

Find me now also over at the other place: philholliger.bsky.social

New paper from my group rdcu.be/eoaRr "Trinucleotide substrates under pH–freeze–thaw cycles enable open-ended exponential RNA replication by a polymerase ribozyme" in Nature Chemistry — great collaboration with attwaterlab.uk.