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Here it is! A huge milestone in neuroscience – the complete connectome of the fly brain from the FlyWire team (FlyWire). In this special issue, we have 9 research articles. I’ll try to summarize them in a couple threads starting here 🧵

Largest brain map ever reveals fruit fly’s neurons in exquisite detail go.nature.com/4dx4qY7

🌍 Excited to share that our paper, "Neural Circuit Mechanisms Underlying Context-Specific Halting in Drosophila," is officially out in Nature today! 🎉Grateful for the support and collaboration that made this possible. Check it out! nature.com/articles/s4158… FlyWire Max Planck Florida Institute for Neuroscience

My lab's first paper is now out nature nature.com/articles/s4158… Check out the cool new data since the preprint work I described a while back. Excited to have this alongside the other FlyWire connectome papers. Grateful to the team! Neha Sapkal Divya S Nino Mancini

Bridging the gap between connectomics and functional understanding requires computational modeling. Shiu et al’s computational model simulates the activity of the entire Drosophila brain, accurately predicting neuronal responses. nature.com/articles/s4158… youtu.be/bZVoPJumx8Y

The most haunting part of this article is when they simulate sugar and the simulated brain responds. Like, there’s no reason to believe they won’t eventually do this with human simulated brains… and if so, why should we believe we’re not simulated? nytimes.com/2024/10/02/sci…

Thrilled that our papers mapping and analyzing the connectome of the complete brain adult fruit fly, including our work with "Tony" Runzhe Yang characterizing the network properties of the brain, have been published at nature!

A historic milestone for neuroscience! It's been a fantastic journey for the #FlyWire Consortium. This special edition of Nature showcases the power of open science, with nine papers that not only describe the fly connectome, but also make discoveries using it.

An exciting day for neuroscience! It was my great honor to contribute to studies led by Philip Shiu and Salil S Bidaye that showcase how the connectome can be used to model the flow of neural activity through the brain and untangle circuit mechanisms underlying locomotion.

Nature research paper: A Drosophila computational brain model reveals sensorimotor processing go.nature.com/3ZNPG3R

Check out our paper on inferring and analyzing the fly effectome (led by the fearless Dean Pospisil and Max Aragon), now in print as part of the FlyWire Connectome collection.

Feeling privileged to work with such brilliant colleagues on studies of this caliber...Enjoy reading! 👇

What an amazing time for neuroscience!! We are proud to be part of this great adventure. Philip Shiu Andrew Seeds Gabriella Sterne, Ph.D. FlyWire

One the cool possibilities from the #fly #connectome is the ability to run simulations. I've finally got around to experimenting with the "Leaky Integrate and Fire" model by Philip Shiu et al. Here are test simulations of 3x Mi1 optic cells, followed by their whole columns