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Biologists once scoffed at Jean-Baptiste Lamarck’s theory that an individual’s life experience could pass on traits to the next generation. The discovery of epigenetics proved such inheritance can occur. quantamagazine.org/the-epigenetic…

⁦@harrylu_TMS⁩ and I are guest-editing a special issue of the 🔥 new journal Addiction Neuroscience on the topic of Emerging Tools to Study the Brain in Addiction Neuroscience We are looking for your original articles, reviews and commentaries. RT🙏 journals.elsevier.com/addiction-neur…

I’m excited to introduce our Retro-Cascorder, out today in nature! This molecular device logs barcoded receipts of gene expression in a temporal genomic ledger. Sequence the ledger --> recover the history of gene expression. nature.com/articles/s4158…

New paper from my group! Munir Gunes Kutlu Jennifer Zachry and Patrick Melugin show that novelty effects on learning are mediated by dopamine release in ways that cannot be explained by prediction-error models, but still robustly influence predictive learning

Check out our latest review where we discuss clinical & preclinical evidence to better understand how ELA shapes the brain during sensitive periods ⁦Lauren Malave⁩ ⁦⁦@MilennavanDijk⁩ ⁦Christoph Anacker⁩ ⁦Nature Portfolio⁩ nature.com/articles/s4139…

Research published in PNAS, co-authored by co-founders of EpiVario Philipp Mews and Berger Lab, demonstrates that fear memories can be controlled through #epigenetic gene regulation via the enzyme ACSS2 #ptsd #neuropsych #upenn prn.to/3QEwXQE

I am incredibly proud of @IsslerOrna and our collaborators for this new work using integrated human-mouse investigations to understand the molecular mechanisms of sex differences in depression. This exciting discovery has inspired my very first "tweetprint". Here we go…🤞🏼

PRESS RELEASE: Philipp Mews Ashley Cunningham, MSc 🧠 Eric J. Nestler, MD, PhD, et al. find #CocaineUseDisorder alters gene networks of #Neuroinflammation and #Neurotransmission in humans - analysis reveals similar changes in the #brain’s functioning in both humans & #mousemodels👉bit.ly/3xjZNxz

Thrilled to share our latest paper in Science Signaling! Our subcellular proteomics study revealed how cocaine dynamically influences protein translocation onto and off chromatin in the nucleus accumbens. Fun project w/ Lucas Sosnick Simone Sidoli & Eric J. Nestler, MD, PhD science.org/doi/10.1126/sc…

Extremely proud to share this work with mastermind Bowen Tan and Tobias Nöbauer representing an awesome collaboration across the labs of Vaziri Lab, Jeffery Friedman, and Eric J. Nestler, MD, PhD now out in Science Magazine. science.org/doi/10.1126/sc…

Scientists at Friedman Brain Institute have decoded how cocaine use disorder skews the modification of proteins in the brain’s “pleasure center” in mice—providing a compendium of data that may inform future therapies for cocaine addiction. Eric J. Nestler, MD, PhD Philipp Mews scim.ag/6GQ

Excited to be able to finally share this work with everyone! Histone variant exchange, where histone protein are swapped for one another, is an interesting mechanism for gene regulation. We show it plays a key role in cocaine responses.