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How do the sperm and egg🥚 fuse to become one in sex? Proteins called fusogens control the process. Scientists have found how Archaea, cells from + than 3 billion years ago, can contain a protein resembling fusogens. ▶bit.ly/3NLTYPq Luca Jovine → bsky.app/profile/jovinelab.org @DdS_ID29 lightsources.org

Congratulations to Егор Седов and Yaron Fuchs for a very interesting story on skin regeneration and homeostasis mediated by THY1 GPI-anchored protein via the YAP-pathway!

IsSDB career award for 2022 to be given to our Eliezer Lifschitz. Congratulations Eliezer!!!! Technion Israel

Malaria parasites utilize two essential plasma membrane fusogens for gamete fertilization pubmed.ncbi.nlm.nih.gov/36241929/?utm_…

IZUMO1 is a sperm fusogen Brukman, Nakajima et al., discovered the first mammalian sperm protein that can fuse cells! doi.org/10.1083/jcb.20… Congratulations to all the coauthors!

IZUMO1 was previously shown to be required for the interaction between mammalian gametes. Nicolas Brukman, Nakajima et al. reveal a second, unexpected function of IZUMO1 as fusogen, providing the first insight into the mechanism of fusion during fertilization. bit.ly/3UMmxAx

doi.org/10.1083/jcb.20…

תרגיל בחיבור – כיצד נוצר עובר? ד"ר ניקולס ברוקמן Nicolas Brukman ופרופ' בנימין פודבילביץ Benjamin Podbilewicz מ-Biology Technion עם חוקרים מ-Tokyo University of Science (TUS) חושפים תפקיד חדש לחלבון IZUMO1 בתהליך האיחוי בין זרע וביצית Journal of Cell Biology technion.ac.il/?p=52385

Yuval Eshed’s summary of 60 years of breakthrough experiments by Eliezer Lifschitz was emotional and a real joy if science: Mazal tov Eliezer and Thais to IsSDB for a wonderful day of developmental biology

Very interesting analysis of our manuscript. Thank you Enrica Bianchi 🏳️‍🌈 and Gavin Wright! Clearly, there are still many interesting questions to be answered...

Congratulations to @PauliGroup,FriedaLeesch & Laura Lorenzo-Orts et al for a beautiful discovery. Great to see it out!

Our results indicate that the extent of fusion correlates with the sperm fertilizing ability, making it a great readout for male fertility tests. You are invited to read the complete story in bioRxiv: doi.org/10.1101/2023.0… Benjamin Podbilewicz Biology Technion Technion Israel

A potential new assay for male infertility? Thanks to the amazing work lead by Nicolas Brukman and Clari Valansi we now have a way to test the capacity of sperm to fuse. elifesciences.org/for-the-press/…

The PVD neuron has male-specific structure and mating function in C. elegans biorxiv.org/content/10.110… Congratulations to Yael Iosilevskii for her story about the highly arborized PVD neuron in males. The PVD is sexually dimorphic and it has a novel function in copulation.

Congratulations to new EMBO member Oded Beja!!!

Bringing together life scientists from Europe and beyond - the meeting of the EMBO communities at its peak #EMBOat60

Congratulations to Sharon, Yael, Alba, Hagar, Meital and Michael for the paper showing that mechanosensory experience alters the PVD’s dendritic architecture in the adult and affects associated behavioral outputs. elifesciences.org/articles/83973

Yael Iosilevskii's image was just selected as Biomedical Picture of the Day: bpod.org.uk

Congratulations to Yael Iosilevskii, David Hall and Menachem Katz for the paper descibing a sexual dimorphism in a pair of sensory neurons in C. elegans and a unique male mating function. pnas.org/doi/10.1073/pn…