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It was great to see all the lively discussions between researchers from all of our institutes at the poster session of the #LED3Symposium. We had a very high quality of posters with an amazing diversity of topics and a lot of interdisciplinary connections.

Great talk by Bert Beerkens at the #LED3Symposium. He talked about his research on the development of labeling reagents for the adenosine A2B receptor using ligand-directed chemistry. Interesting application of N-acyl-N-alkyl sulfonamide (NASA) chemistry.

Great talk by Nataliia Machushynets at the #LED3Symposium. She talked about her research in the group of Gilles van Wezel 💙💛 into new tridecaptin antibiotics with enhanced biological activity. An exciting interdisciplinary project across several LED3 hub (inactive account) groups.

Great science at the Flash Talk session of the #LED3Symposium. Amazing to see all the diverse topics including antibiotics, cyclic peptides, GPCRs, genome mining, hydrogels, covalent inhibitors and many more that are covered in interdisciplinary projects within the LED3 hub (inactive account).

Great talk by Sophie Wintermans at the #LED3Symposium. She talked about her PhD research in the group of Marta Artola into a high throughput screening method for RNA-binding small molecules on the example of the PreQ1 riboswitch. biorxiv.org/content/10.110…

The final keynote lecture of the #LED3Symposium was given by Nathaniel Martin. He talked about his group's amazing research into inhibitors of the cancer driver protein Nicotinamide N-methyltransferase (NNMT). sciencedirect.com/science/articl…

At the #LED3Symposium, we also announced next year's #LED3Lectures with an amazing program including Emily Balskus, Andrew Leach, Tjeerd Barf, Picotti Lab, Andrea Rentmeister, Jeff Kelly, John P. Overington, Kim Lewis, Ed Tate and Jay Keasling.

LED3’s first PhD/Postdoc symposium was a big success!🎉 Researchers from different Leiden Science institutes presented their interdisciplinary research on Early Drug Discovery. Read more about the collaboration: universiteitleiden.nl/en/science/led3 #LED3Symposium

Great paper from the groups of Joanna McGouran and Sander van Kasteren with first author @SeanMcK27 in RSC Chemical Biology. Fully-functionalized probes based on the metal chelator 8-mercaptoquinoline for affinity-based protein profiling of metal-binding proteins. doi.org/10.1039/D4CB00…

Our latest paper is just out in ACS Chemical Biology. Novel quenched fluorescent activity-based probes for serine proteases based on phosphinate esters. This work was part of the PhD of Jan Pascal Kahler. pubs.acs.org/doi/10.1021/ac…

Can you improve an antibiotic that has been in clinical use for 75 years? The group of Nathaniel Martin of the LED3 hub (inactive account) addressed this question by developing bacitracin analogs with enhanced activity against vancomycin-resistant enterococci (VRE). pnas.org/doi/10.1073/pn…

MC4DD: New EU consortium on drug discovery dedicated to macrocycles. 8 universities and 6 industry partner join forces to advance the science of macrocycles as drugs. More information: MC4DD.com

A focused library of site-specifically acetylated Max transcription factor analogs was chemically synthesized to dissect the role of Lys-acetylation in its DNA binding activity NEW #ASAP by @jbaram90 @afek7afek Read it here: go.acs.org/a9D

Amazing news that two projects involving LED3 hub (inactive account) scientists have been awarded funding through NWO Funding Open Competition M2 grants. Congratulations to Sebastian Pomplun and Matthias Barz from the LACDR as well as Sander van Kasteren from the LIC. nwo.nl/en/news/twenty…

Can you simultaneously improve the potency and safety profile of a clinically used antibiotic? The group of Nathaniel Martin of the LED3 hub (inactive account) presents the guanidino lipoglycopeptide antibiotic class with potent antibacterial activity in Science Translational Medicine. science.org/doi/10.1126/sc…

Come join us at EPFL! We are looking to fill a new position for a Tenure Track Professor in Chemical Biology! Find all info how to apply here: epfl.ch/about/working/…

Thrilled to share our latest work on the late-stage, site-specific chemical insertion of aromatic PTMs into proteins, published today in J. Am. Chem. Soc. A big thanks to LashuelNeuroLab for the exciting collaboration. Congratulations to Lin, Shaswati, and the team! pubs.acs.org/doi/10.1021/ja…

We had a small change in the program. The LED3 hub (inactive account) Lecture by Paola Picotti Picotti Lab was moved to February 6th, 2025.

📢 JOB ALERT 📢 My team Molecular Machine Learning is searching for a #postdoc with a background in medicinal chemistry! 👩‍🔬👨‍🔬🧪 Do you have the experience? Are you eager to contribute to #AI for discovering new drugs? 👉Then DM me! Funded by European Research Council (ERC) and located at TU Eindhoven 🚀