🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Here we go.! Our article on #inflammasome role in #COVID-19 severity and #bat immune tolerance to host viruses. We also report intriguing bat variations in inflammasome complex impacting its function. Done by Sahana and Disha, fantastic trainees in lab.! jlb.onlinelibrary.wiley.com/doi/10.1002/JL…

Check out the new review from raju karki on #CytokineStorm out today Trends in Immunology describing the underlying mechanisms, connections with cell death, and potential treatment strategies. Great work Raj! #Immunology St. Jude Research authors.elsevier.com/a/1dKcL5Eb0RmK…

Our study on how gut bacteria might be beneficial for our health through their ability to metabolize phytoestrogen advances.sciencemag.org/content/7/28/e… Article by Elana Spivac highlighting our study inverse.com/mind-body/diet… Inverse Science Advances #Microbiome #MultipleSclerosis

Congratulations to Dr. Nitin Karandikar for renewing a VA Merit grant and receiving the VA Senior Clinician Scientist Investigator (SCSI) Award! Nitin Karandikar bit.ly/3hJUTmB

Inflammatory Cell Death, PANoptosis, Mediated by Cytokines in Diverse Cancer Lineages Inhibits Tumor Growth immunohorizons.org/content/5/7/568

We need to agree on and publish a perspective on equally contributing authorship order. Is it ok to switch an order of equally contributing authors (so that each co-first author puts themselves first on CV). Please comment and indicate if you’re PI/student/postdoc/fellow/editor.

We have an exciting lineup of speakers this year talking about immune responses to infection. John T. Harty Lab @joannflynn19 #AIC2021 #SaturdaySession autumnimmunologyconference.org/program-details

Out online today: one of our newest postdocs Yaqiu discusses programmed cell death pathways, molecular crosstalk among #pyroptosis #apoptosis #necroptosis, and the evidence for PANoptosis and the PANoptosome complex. Great work Yaqiu! St. Jude Research sciencedirect.com/science/articl…

So proud of my grad student Alejandro Canaria, Ph. D for getting his first paper out! Turns out STAT3 may not be as important for Th17 cell differentiation as we thought!

The Kanneganti lab is hiring postdocs! Especially looking for #virus expertise at the moment, but always open to anyone with an interest and a passion for innate immunity, cell death, and disease mechanisms. #sciencetwitter #AcademicTwitter #immunology nature.com/naturecareers/…

This study also discovered three functional classes of caspase-4 in nature. One class is like human casp4. Second is like casp1. Third is the first discovered caspase that binds LPS and is an ICE. This latter class bypasses inflammasomes to promote IL-1 release.

Congrats to Frank Sangjoon Lee and the whole team! New work nature describing how multiple inflammasome sensors come together with other cell death proteins during infection to form a mega-cell death complex (AIM2-PANoptosome) for host defense St. Jude Research nature.com/articles/s4158…

A great honour to meet Prof. Thirumala Devi Kanneganti. What an inspiration she is!! 🙏 Kanneganti Lab Dr.D Nageshwar Reddy Dr G V Rao Sundeep Lakhtakia Dr. Sasikala Mitnala. Standing ovation while being felicitated AIG Hospitals

Congrats raju karki on new work showing interplay between ADAR1 and ZBP1 prevents cell death. In cancer, targeting this pathway with a combination of IFN and a nuclear export inhibitor activates cell death and regresses tumors! Great work! Cell Reports cell.com/cell-reports/f…

New cell death review focused on the totality of #biological effects in cell death and how taking a holistic view led to an integrated inflammatory cell death concept, PANoptosis. Congrats to Jessica Gullett on her 1st article in our group! St. Jude Research mdpi.com/1611934

Great to see these 3 papers! These further confirm what we mechanistically reported last year Kanneganti Lab St. Jude Research Cell Reports: ADAR1 restricts ZBP1-mediated cell death and inflammation, which we targeted to regress #cancer in preclinical models cell.com/cell-reports/f…

Inpp5d deletion in microglia leads to robust Abeta plaque encapsulation and greatly improved neuronal health Alzheimer's Assoc CWVA 1 of 3 interesting papers on microglial Inpp5d in AD at Alzheimer's & Dementia Journals. Congrats to Josh Samuels and the team Price Lab @ University of Virginia alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…

Exciting times St. Jude Research: introducing the new Center of Excellence for Innate Immunity and Inflammation w/ Thirumala-Devi Kanneganti to bring together leaders in the field to define fundamental mechanisms and translate to disease treatments. Consider joining! stjude.org/research/cente…

NLRP12-PANoptosome activates PANoptosis and pathology in response to heme and PAMPs. cell.com/cell/fulltext/…. Congrats to Thirumala-Devi Kanneganti Kanneganti Lab on the outstanding work Cell