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Congrats to our newest NSF GRFP awardees: maya bluitt, jp flores (he/him), Sarah Anne Howard, and Nick Randolph! Plus honorable mention for Cassie Phillips, Nina Nishiyama, Margaret Dedloff, and Brandon Pratt. What a great way to start Graduate Student Appreciation Week!

Authored by Andrew G. Soerens et al, we show that #Tcells are capable of proliferating in response to iterative stimulation for over 10yrs! And produce enough progeny to occupy a volume 30,000x the Earth's volume! nature nature.com/articles/s4158…

Now in Science Magazine , Fidelle, Rauber, Carolina Alves Costa Silva, MD, PhD, Zitvogel, & al. show after #ABX treatment in mice, #Enterocloster recolonize gut → ↘️ MAdCAM-1. α4β7+ #Tr17Cells can then traffic from gut to #tumors & compromise #checkpoint #immunotherapy! bit.ly/Sci_abo2296

Congratulations👏 to graduate student, James Isaiah (Ike) Emerson, in the Frank Conlon Lab. He recently received the Marzluff RNA Fellowship Award from the UNC RNA Discovery Center UNC Lineberger The RNA Society. #cardiovascular #research

🚀 PUBLISHED Nature Genetics 📰 Noncoding variants alter GATA2 expression in rhombomere 4 motor neurons and cause dominant hereditary congenital facial paresis 🧑‍🤝‍🧑 Elizabeth C. Engle, Alan P. Tenney, Silvio Alessandro Di Gioia, Bryn D. Webb and team 👇🏼 go.nature.com/3Not8i0

Excited to share our new paper from the Engle lab and collaborators.

Our latest work is out Immunity ! Find out how we used surface proteome analyses to explore circulating and tissue-resident memory T cells diversity across tissues & many more!👇 authors.elsevier.com/c/1hL2j3qNrUu3… Mackay Lab Doherty Institute #teamTRM 🧪🔬🧵

As promised a short 🧵 on our latest work just out in Science Immunology! Spearheaded by talented PhD student Anne Onrust and Hi-C wizard @G_Stik 💪 What did we find? A central theme in my lab is understanding immunological memory in T lymphocytes. After a naive T cell has been 1/

Congratulations Alec Plotkin for winning a best poster award at data science day for work predicting CD8 T-cell fates with Justin Milner :) Truthfully, this a picture from last week, but is the same poster. Great job Alec.

A new probiotic-guided CAR-T platform uses engineered bacteria to infiltrate and produce synthetic antigen targets, enabling CAR-T cells to find, identify, and destroy tumor cells in situ. 📄: scim.ag/4xG #SciencePerspective: scim.ag/4xF

🧬 Insights into the factors controlling immunity 🦠 Strategies to harness the immune system 🧪 Join us today for a groundbreaking seminar to study the physiological puzzles with Dr. Brian D. Brown Mount Sinai Health System! Host: Brandon Pratt Brandon Pratt of Milner Lab Justin Milner

Excited to share our paper in Nature Immunology describing X-CHIME, a CRISPR-based system for knocking out genes in immune cells constitutively, inducibly, sequentially, and lineage-specifically. nature.com/articles/s4159…

Introducing TICTACs, tumor immune cell targeting chimeras that engage CD206, a marker of immune suppressive TAMs, and drive internalization of cell surface targets like SIRP1a. Congratulations postdocs ⁦Mari Morimoto⁩ and Nick Till on this preprint! biorxiv.org/content/10.110…

Very excited by our results nature showing that IL4R signaling is strongly enriched in myeloid cells that infiltrate mice and lung cancer lesions nature.com/articles/s4158…

Our self-propelled CAR T cells expressing synthetic “velocity” receptors infiltrate pancreatic tumors like its butter (bottom). Control CAR T cells can’t (top). Game over. Works in any solid tumor; can transform any CAR T of your choice into a Ferrari. biorxiv.org/content/10.110…

Happy to share our new work describing DESynR genes! The evolution of new human protein-coding genes relies on repurposing protein domains from ancestral genes, rather than de novo sequence creation. New genes evolved from old parts, and while we have methods that enable

Online now: Enhancer-driven gene regulatory networks reveal transcription factors governing T cell adaptation and differentiation in the tumor microenvironment dlvr.it/TL09jV

Fantastic talks Helen Lazear and #brandonpratt 🏆, great science, lots of learning and networking, representing UNC at the Southeastern Immunology Symposium #SIS2025 UNC Lineberger UNC Microbiology and Immunology Department #JustinMilner #JennyTing