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Researchers have created the largest and most detailed wiring diagram of a mammalian brain to date, by mapping cells in a cubic millimetre of a mouse’s brain tissue go.nature.com/3G1eihE

This groundbreaking research was co-led by Princeton Neuroscience Institute’s Sebastian Seung: bit.ly/3RLXKfW

In 1979, eminent biologist Francis Crick said, “It is no use asking [neuroscientists] for the impossible, such as, say, the exact wiring diagram for a cubic millimeter of brain tissue and the way all its neurons are firing.” 46 years later, that exact wiring diagram is complete.

For the first time, scientists have mapped the half-billion connections that allow mice to see. It is the largest and most detailed such rendering of neural circuits in a mammalian brain. Read full story: bit.ly/3XUisOn

This research by Sebastian Seung and his collaborators, including its spellbinding visuals, was featured in The New York Times this week. The team charted the activity and structure of 200,000 cells in a mouse brain. ⬇️ nytimes.com/2025/04/09/sci…

It took more than a decade to trace the 130,000 connections in a fruit fly's brain. With the map in hand, researchers are turning to the next step in connectomics: building simulations. By Laura Dattaro thetransmitter.org/connectome/con…

Sign up to join a community of Princeton alumni, students, faculty, staff and friends who are committed to making the case for America’s colleges and universities: bit.ly/3YArv7t

🎉 Congrats to PNI’s Jonathan Cohen, Tom Griffiths (Griffiths Computational Cognitive Science Lab), and Ken Norman (Norman Lab) for being awarded Princeton Engineering Innovation Grants! Their projects bridge neuroscience, AI, and quantum modeling to understand how the brain learns, perceives, and decides.

In 1981, Princeton University's John Hopfield received an NSF grant (~$300K) for the, then, obscure field of artificial neural networks. Today, that research powers a multibillion dollar AI economy and earned him a Nobel Prize. npr.org/2025/05/08/nx-…

🎉Congrats to NEU undergraduate Jeffery Chen '25 and PNI grad student Serene Dhawan, who were both recognized for their outstanding ability to communicate complex science at Princeton University Research 10th annual Princeton Research Day! pni.princeton.edu/news/2025/neur…

New op-ed in nature: The Trump administration's assault on freedoms and the rule of law is an existential threat to US science. We urge scientists to speak out in defense of freedoms, not just funding. With Andrea Liu Penn and Sidney Nagel of The University of Chicago nature.com/articles/d4158…

A team of researchers has developed a precise map of the vision centers of a mouse brain, which promises to accelerate the study of normal brain function: seeing, storing and processing memories, and navigating complex environments. bit.ly/4jS63TX

Nice story today in the The Daily Princetonian on the Chris Chang Lab and their work on “Metals, molecules, and medicine: chemical biology’s influence on health and sustainability.” Read it here: bit.ly/4miZzPw

In our latest edition of “This paper changed my life,” Bradley Dickerson discusses how a 1940s fly neuroanatomy paper taught him how to think about circuits and behavior being greater than the sum of their parts. thetransmitter.org/this-paper-cha…

1/ Excited to share our recent work in #ICML2025, “A multi-region brain model to elucidate the role of hippocampus in spatially embedded decision-making”. 🎉 🔗 minzsiure.github.io/multiregion-br… Joint w/ FieteGroup Jaedong Hwang, Brody Lab, Princeton Neuroscience Institute ⬇️ 🧵 for key takeaways

For her senior thesis, Kajal Schiller '25 designed a computer simulation game to measure whether socioeconomic status might determine how likely people are to take advantage of resources that can help them solve problems. bit.ly/4kSPWGu

🎓 Congratulations to the Neuroscience Class of 2025! At PNI’s Class Day, seniors received their certificates, shared their research, and celebrated with family, friends, and faculty 🧠 pni.princeton.edu/news/2025/grad…

“Like a group of skiers descending a mountain, each [neuron] prefers a slightly different path, but all are shaped by the same slope,” says Princeton University’s Tatiana Engel on her lab’s new nature study of how the brain makes decisions. 📰: pni.princeton.edu/news/2025/all-…

Out today in nature: we show that individual neurons have diverse tuning to a decision variable computed by the entire population, revealing a unifying geometric principle for the encoding of sensory and dynamic cognitive variables. nature.com/articles/s4158…

When faced with the same evidence, people can arrive at different outcomes, especially when the decision is difficult. For instance, two different drivers in rush hour traffic see the same congested road, yet one might speed up to merge while another cautiously brakes. How the