So freakin proud of this one!! Tom Ekstrom did some amazing work on this one! So many cool insights and unexpected turns! #PauseRelease #Transcription #Enhancer #Looping #ChemicalScreen

#GUTOnline paper by Ekstrom et al on "Glucocorticoid receptor suppresses GATA6-mediated RNA polymerase II pause release to modulate classical subtype identity in pancreatic cancer" via bit.ly/3Q1wUzF Amro Abdelrahman, MBBS, MS Prof. Steven A. Johnsen, Ph.D. #PancreaticCancer

#GUTOnline paper by Ekstrom et al on "Glucocorticoid receptor suppresses GATA6-mediated RNA polymerase II pause release to modulate classical subtype identity in pancreatic cancer" via bit.ly/3Q1wUzF Amro Abdelrahman, MBBS, MS Prof. Steven A. Johnsen, Ph.D. #PancreaticCancer

#GUTOnline paper by Ekstrom et al on "Glucocorticoid receptor suppresses GATA6-mediated RNA polymerase II pause release to modulate classical subtype identity in pancreatic cancer" via bit.ly/3Q1wUzF Amro Abdelrahman, MBBS, MS Prof. Steven A. Johnsen, Ph.D. #PancreaticCancer

A fantastic postdoc opportunity available for talented PhD graduates to work in our CRUK funded PhD project. This is a great multidisciplinary project towards prevention breast cancer: jobs.manchester.ac.uk/internal/Job/J… Manchester Breast Centre Manchester Cancer Research Centre UoM Biology, Medicine and Health

We are now on BlueSky too! bsky.app/profile/profjo…

Super excited to be back on board as Associate Editor at Bill Dynan - NAR Cancer Editor NAR Cancer is a great place to bring your cancer research papers, where you can be ensured a quality peer review at a top notch academic publisher (with full open access!).

Mayo has played such a special & central role in my life & my career! Since my first visit to the Mayo Clinic when interviewing for the Mayo Clinic Graduate School of Biomedical Sciences in 1999 till 20 years later becoming a staff member and Professor in Mayo Clinic Gastroenterology & Hepatology in 2019, this place remains in my blood.

Super happy to see this commentary in ⁦Gut Journal⁩ about our recent work!!! Truly one of the most exciting and rewarding projects of my career. So happy to have worked with Tom Ekstrom on this exciting project! #FuturePI #ProudMentor #BoschStiftung gut.bmj.com/content/early/…

#GUTImage from the paper by Ekstrom et al entitled "Glucocorticoid receptor suppresses GATA6-mediated RNA polymerase II pause release to modulate classical subtype identity in pancreatic cancer" via bit.ly/3SHMGkH Amro Abdelrahman, MBBS, MS Prof. Steven A. Johnsen, Ph.D. #PancreaticCancer

.Prof. Steven A. Johnsen, Ph.D. and team uncover the transcriptional control and role of glucocorticoid receptor agonists in controlling #PDAC molecular subtype identity. 📚 More in Gut Journal: bit.ly/3FSGxPO

Check out our preprint on #RELA and #RELB function in #PDAC downstream of #canonical and #noncanonical #NFKB signaling. Excellent work from the PhD work of Dr Joana Aggrey-Fynn, who will soon begin her postdoc at Fred Hutch Cancer Center. #pancreaticcancer biorxiv.org/cgi/content/sh…

Final COMPASS trial data advanced #PDAC ➡️268 WGS& 253RNA-seq ➡️basal-like& hi GRIm-S ⬇️OS, both unique TME inc CD8 variation,NB primaries vs mets ➡️LTS :HRD, KRAS WT ➡️KRAS major enriches basal, >type II DM ➡️LAPC≠intact SMAD4 ➡️47% receive 2nd line tx nature.com/articles/s4146…

New in Cell Death & Disease: Targeting FOSL1/RELA suppresses #metastasis in PDAC by disrupting a pro-metastatic transcriptional program. Led by Joana Aggrey-Fynn during her PhD in the Prof. Steven A. Johnsen, Ph.D. lab! 📖 nature.com/articles/s4141… #PancreaticCancer #CancerResearch #PDAC

Informative #GUTVideo by Ekstrom et al on the paper "Glucocorticoid receptor suppresses GATA6-mediated RNA polymerase II pause release to modulate classical subtype identity in pancreatic cancer" via bit.ly/4fhFYwb Paper via: bit.ly/3SHMGkH Prof. Steven A. Johnsen, Ph.D.

Looking forward to another great talk by @ckadoch Kadoch Lab here at the #EpiSociety2025 meeting!