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A mechanism of lysosomal calcium entry | Science Advances science.org/doi/full/10.11…

I am sad to report that Bill Catterall has died. He was an enormous presence University of Washington.

Matthew Freeman and Fran Ashcroft discuss "The Mould in Dr Florey's Coat" by Eric Lax in this #podcast podcasts.ox.ac.uk/good-science-r…

"A fundamental mistake in receptor theory has led to an enduring misunderstanding of how to estimate the affinity and efficacy of an agonist." arxiv.org/abs/2402.14617

38 years ago a woman in Coventry sent a letter to some scientists. That letter went on to be the most important in Alzheimer's research. Last year, I met Carol Jennings, who wrote it. 1/ thetimes.co.uk/article/e78c47…

Our latest paper on Extracellular modulation of TREK2 K2P channels by nanobodies is now finally online in Nature Communications nature.com/articles/s4146…

Are you thinking about starting your own group? Thinking of sponsors for a Fellowship application. Then consider coming to Department of Biochemistry at Oxford University ! Would be great to see some computational fellows!

Structure of Kir7.1 biorxiv.org/content/10.110…

Our latest Preprint on structure of THIK-1 K2P Channel - lots of new features including a lower 'Y-gate'. biorxiv.org/content/10.110… Also exciting that Dan Minor's group Dan Minor have almost identical results and some additional structures - also on bioRxiv Biophysics

Exciting times for K2P channels indeed!

I feel hungry after just a few hours, but hibernating squirrels don't even after several months. This remarkable feat is possible due to reversible central hypothyroidism. A new study from the Gracheva lab by Sarah Mohr and Rafael Dai Prá rdcu.be/dNmeC

scilifelab.se/event/linkopin…

One of the unforgettable moments at the 2024 Ion Channels GRC was the closing lecture by Fred Sigworth. If you missed it, here it is.. youtu.be/db1afWzokOU?si…

Structures of TASK-1 and TASK-3 K2P channels provide insight into their gating and dysfunction in disease biorxiv.org/cgi/content/sh… #biorxiv_biophys

Our latest Preprint: More new CryoEM structures of TASK1 and TASK3 K2P channels including the G239R disease-causing mutant structure of TASK3 (KCNK9 Imprinting Syndrome/Birk Barel Syndrome) biorxiv.org/content/10.110…

Want to know when is a hydrophobic gate not a hydrophobic gate? Read more here in this Viewpoint: rupress.org/jgp/article/15…

Do not forget to submit an oral abstract for 8th RSC-BMCS / SCI Symposium on Ion Channels as Therapeutic Targets! This symposium will showcase the most recent advances to aid the design of new ion channel therapeutics and promote interaction between scientists with a shared