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🧬 Researchers establish FOXA1 as a multifaceted oncogene, with distinct mutational classes divergently evolving to drive prostate tumorigenesis or therapy-resistant progression. 👉 Science Magazine | bit.ly/3Gis4Ng

📈 Scientists showed that dysregulated ubiquitination and turnover by the cullin 3 ZBTB2 E3 ligase complex induce the upregulation of the short isoform of NSD3, which confers PARPi resistance in prostate cancer cells and #mCRPC samples. Molecular Cell | bit.ly/4lbOXRW

💊 Researchers at Dana-Farber uncovered a common MUC1-C-dependent pathway in treatment-resistant CRPC/NEPC progression and identified MUC1-C as a target for their treatment with a M1C antibody-drug conjugate. JCI insight | bit.ly/4lzPH2T

📖 The authors summarize the latest drug treatment strategies and clinical concerns in the management of advanced prostate cancer in Japan, based on the Japanese Clinical Practice Guidelines for Prostate Cancer published in 2023. 🔗 bit.ly/3TSzQ3z

🥼 Investigators demonstrate the feasibility of using predicted structural models for optimizing lead compounds, and HEAL-116 provides a promising avenue for the clinical validation of 3βHSD1 inhibitors in prostate cancer therapy. PNASNews | bit.ly/3IpQipq

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New work led by Dr. Jan-Ake Gustafsson at University of Houston shows that #EstrogenReceptor β is critical for maintenance of basal cells in the prostate and controlling prostatic inflammation. Read the PNASNews study: bit.ly/4eB8CrL

NUSAP1 is a crucial mitotic regulator that plays a significant role in various cancers, including prostate cancer. A new #review discusses the roles and mechanisms of NUSAP1 in human cancers. 🔗 bit.ly/44DcV1d

New findings from researchers in China underscore the pivotal role of YY1 in the hypoxia/HIF-1α pathway in tumor-associated macrophages and support the targeting of YY1 for treating #ProstateCancer. 📚 Read the Nature Communications study: go.nature.com/4eF3C5r

Scientists in China have shown that TRIM26, an E3 #UbiquitinLigase, drives #ProstateCancer malignancy and may be an attractive target for treatment. 🥼 Read the study: bit.ly/40a8KIX

A new study led by Dr. Nicolas Herranz (Nicolás Herranz) at Vall d’Hebron Institute of Oncology (VHIO) underscores the potential of CDK4/6i in #ProstateCancer therapy, particularly when administered under biology-driven sequential use of senolytic therapy or PARPi. 📌 Learn more: bit.ly/40PWkGe

🦠 The antitumor activity of a 56mer aptamer helped support glutamine as an oncometabolite in prostate adenocarcinoma that can be targeted to sensitize tumors to hormone therapy. Cancer Research | bit.ly/46fHmNo

🔬 Researchers created an urinary large extracellular vesicles-centric proteomic approach for early prostate cancer identification. ACS Analytical Chemistry Journals | bit.ly/3IsSo8j

🔎 Scientists investigated #androgen receptor involvement in pain sensitivity and sex differences in pain perception. Manipulating androgen signaling in sensory neurons may offer a promising approach to managing mechanical pain. 🔗 bit.ly/3GvWjR9

Today in Nature Genetics! Scientists report a hierarchical network of TFs governed by NKX2-1 in critically regulating chromatin remodeling and driving luminal-to-neuroendocrine transformation in neuroendocrine #ProstateCancer. 🌐 go.nature.com/4lCMu2N

Dr. Neil Bhowmick and colleagues depletion of glutamine with a cyanobacteria-derived catalytic aptamer blocks FGF8 expression and sensitizes hormone refractive prostate tumors to androgen receptor inhibitors. 🩺 Cancer Research | bit.ly/46fHmNo

Scientists engineered an enhanced PSMA/CD3 bispecific antibody by incorporating the extracellular domain of CD80, which provides a co-stimulatory signal to counteract T-cell inhibition in #ProstateCancer. 📖 Discover more: bit.ly/46Zp3fD

Researchers investigated the regulation and function of PD-1 expression in #ProstateCancer and revealed the impact on the tumor microenvironment. 💡 Learn more in Cancer Research: bit.ly/3UhJixT

Hear from Dr. Cathi Murphey as she discusses the validation of cell isolation technologies for isolating different cell subsets and improving purity for #chimerism analysis in this STEMCELL Technologies webinar. 🥼 bit.ly/3FCBkvi

This Molecular Oncology study by Dr. David Goode and team redefines focal neuroendocrine differentiation as a distinct #prostate cancer pathology. 🔎 Discover more: bit.ly/4lWjB1G