"#Parkinsons disease is evolving from a clinical to a biomarker-supported diagnostic entity, for which earlier identification is possible, different subtypes with diverse prognosis are recognised, & novel disease-modifying treatments are in development" thelancet.com/journals/laneu…

Congrats Andrew, well deserved ... now you get to drop “acting” director from your email signature 🦾 #CARD nia.nih.gov/news/dr-andrew…

A new work from our lab (in collaboration with many exceptional labs at Test Account) by @Da_Mesquita_S (now PI Mayo Clinic), attempting to link #MeningealLymphatics to human Alzheimer's (please read the supplemental figures - a lot of cool data there!) || nature.com/articles/s4158…

Congrats Andrew C. Yang RyanVest Fabian Kern 🦋 @fabianmkern to human brain vascular map & role in AD in collaboration with @SiegenthalerLab and Andreas Keller biorxiv.org/content/10.110…. Discovered 2 types of pericytes, one differentially lost in AD, PV fibroblast types & tie AD GWAS to vasculature

and here is our simple web browser developed by Patricia Losada to look up the expression of your favorite gene in the human brain vasculature and in AD twc-stanford.shinyapps.io/human_bbb/

Does Alzheimer’s disease pathology spread through the brain consistently across the population? We delve into this in our paper “Four distinct trajectories of tau deposition identified in Alzheimer’s disease”, now online at Nature Medicine. nature.com/articles/s4159… Thread below 1/

Simultaneous Detection of Six Isoforms of Tau Protein in Human Cerebrospinal Fluid by Multidimensional Mass Spectrometry-Based Targeted Proteomics pubs.acs.org/doi/10.1021/ac…

Spatial transcriptomics at subspot resolution with BayesSpace go.nature.com/3gd7nBw

First author Edward Zhao goes #behindthepaper on a tool for clustering analysis and resolution enhancement of spatial transcriptomics data bioengineeringcommunity.nature.com/posts/spatial-…

A multi-step nucleation process determines the kinetics of prion-like domain phase separation: nature.com/articles/s4146…

🧵 One of the most asked questions about #ParkinsonsDisease is: what are the symptoms? Here are some fast facts to help keep you informed. Was there anything listed here you hadn’t heard of before? Let us know in the replies! (1/2) #tremor #insomnia #neurotwitter #neurology

Interesting finding with pretty vast implications

Biomarker of synapse dysfunction [neuronal pentraxin 2 NPTX2] in CSF is the first to change in familial frontotemporal dementia #FTD ahead of #NFL and neuroinflammation markers 👍to Emma van der Ende and GENFI team DOI: 10.1093/brain/awab382 Brain GENFI #SynapticHealth

Together with Anoop Arunagiri and other colleagues we launch frontiersin.org/research-topic… Looking forward for your contributions on multiple flavors of #Protein_homeostasis; #Protein_aggregates; #Phase_separation; #Protein_condensates; #Amyloids and #Proteotoxicity among others!

We had a #Christmas event after two years!! Fabulous Brazilian Steakhouse lunch at Casa do Brazil! #MerryChristmas to everyone and #HappyHolidays! Stay Safe everyone! #AcademicTwitter #Christmas2021 #biology

Just out in The Lancet Neurology — our review of neuropsychiatric features of #Parkinsons MDS UCL Institute of Mental Health UCL Brain Sciences MovementDisordersUCL thelancet.com/journals/laneu…

We are #HIRINGNOW #postdocs with #Biochemistry #biophysics experience! Project involves #stemcells #singlecell #multiomics #CryoEM for #Parkinsons #research. DM for more info or use link below: linkedin.com/posts/mitchell… #Parkinson #tau #STEM #postdocjobs #protein