Excited to share my latest work from the @MarraffiniLab, in collaboration with Phoebe Rice, now online nature!! nature.com/articles/s4158… We report the discovery of DNA glycosylases that provide anti-phage defense in bacteria! A thread 🧵: 1/

IISc turns 115 today! 🎉 ​The vesting order for establishing IISc was ​published on 27 May 1909, officially bringing the Institute into existence. ​​ iisc.ac.in/wp-content/upl…

Looking forward to the NY Area CryoEM meeting Thursday! Some great talks lined up from Puja Majumder, sacha salphati, Gabriele Cerutti, @SamSustek, Lars Dingeldein, Jianping Li, Ziao Fu and Yan Li, plus many exciting posters! 🙏 for support from sponsors ⬇️, & see you Thurs! ❄️🔬

Deeply grateful to Government of lndia Updates for this selection. My gratitude to my mentors, colleagues Molecular Biophysics Unit, IISc , students and family for their unwavering support. A special thanks to all past and present @Penmatsalab members who made this happen. Congratulations to all winners of RVP2024.

What a great day for Aravind Penmatsa.

Many thanks to DBT/WT India Alliance for showcasing our research and supporting us over the years!

CRISPR has long been likened to a kind of genetic scissors, but a new study from the @MarraffiniLab finds that CRISPR-Cas10 employs an additional strategy to protect against viruses: a molecular fumigator. #RockefellerScience rockefeller.edu/news/36859-a-n…

Very excited to share our recent work revealing a new chemistry for CRISPR! Thankful to Christian F. Baca, Patel lab and @MarraffiniLab ! The CRISPR-associated adenosine deaminase Cad1 converts ATP to ITP to provide antiviral immunity: Cell cell.com/cell/fulltext/…

Cad1 turns ATP into phage poison Highlight of paper by @MarraffiniLab Cell reporting type III CRISPR-Cas accessory effector, Cad1, which deaminates ATP into ITP, causing ITP accumulation & host growth arrest, thereby inhibiting phage propagation cell.com/cell-host-micr…

Many thanks to the authors for this nice preview of our recent work describing a new chemistry of CRISPR systems! cell.com/cell-host-micr…

Thankful to Genetic Engineering & Biotechnology News for covering our recent work on Cad1 defense system. CRISPR Study Reveals Yet Another Antiviral Mechanism genengnews.com/topics/genome-… via Genetic Engineering & Biotechnology News

Review Molecular Cell Nucleic acid recognition during prokaryotic immunity @MarraffiniLab Christian F. Baca cell.com/molecular-cell…

Cat1 forms filament networks to degrade NAD+ during the type III CRISPR-Cas antiviral response Science Magazine Puja Majumder Christian F. Baca @MarraffiniLab science.org/doi/10.1126/sc…

CRISPR continues to amaze me! Excited to share the last project from my PhD, co-led by the incredible Puja Majumder and myself! We studied the CRISPR effector Cat1, which forms beautiful filament networks to degrade NAD+. Out today in Science Magazine! science.org/doi/10.1126/sc…

CRISPR associated filament networks providing antiviral immunity! I am very excited to share our recent work co-led by amazing Christian F. Baca and me. The work is now online in Science Magazine! Science.org/doi/10.1126/sc…

Take a look on our recent work on expanding the CRISPR-toolbox! The work is highlighted by The Rockefeller University! Huge thanks to the co-lead author Christian F. Baca, Dinshaw Patel lab (MSKCC) and Luciano Marraffini lab (RU)! rockefeller.edu/news/37733-res…

CRISPR-Cas response, once thought to act exclusively on nucleic acids, can be mediated by a diverse range of molecular mechanisms Science Magazine Puja Majumder Christian F. Baca @MarraffiniLab science.org/doi/10.1126/sc…

NYSBC Monthly Webinar Series: Please join us for a webinar on Structural Basis of a Filamentous CRISPR Effector by Dr. Puja Majumder from Memorial Sloan Kettering Cancer Center. All are welcome to attend. Registration is at no-cost, but sign-up is required: us02web.zoom.us/webinar/regist…

The next #CryoEM Current Practices Webinar speaker will be Puja Majumder from Dinshaw Patelss lab Memorial Sloan Kettering Cancer Center speaking on "From Micrographs to Maps: Structural Basis of a Filamentous CRISPR Effector Revealed by Cryo-EM" 7/31/2025 at 12 PM ET / 9AM PT us02web.zoom.us/webinar/regist…

August update: Proposal in Ludwig fellowship is through!