Risk factors, such as hypertension, obesity and physical inactivity are targets of #dementia prevention. New research suggests that many inflammatory diseases (gastritis, duodenitis, erysipelas) may be equally strong long-term predictors of dementia. alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…

NEW multicohort study: #BingeDrinking a long-term #dementia risk factor even if a person usually drinks moderately. Alcohol-induced loss of consciousness linked to a 2-fold increased dementia risk among both moderate and heavy drinkers. ja.ma/32dDz1G

For comparison, mild traumatic brain injury with loss of consciousness is also associated with a ~2-fold increase in the risk of dementia diagnosis ja.ma/3jS9drA

Amyloid and tau have dominated pathophysiological models of dementia aetiology. This preprint identifies 15 novel proteins associated with cognitive decline and dementia. Whitehall II Study #ARIC Joni Lindbohm @gottesman_lab Epi of Ageing Gill Livingston medrxiv.org/content/10.110…

Multicohort study links #infections to #dementia risk: - stronger effects on vascular dementia than Alzheimer’s - attributable to general inflammation rather than any specific pathogen - systemic infections sufficient to affect the brain. @UK_Biobank thelancet.com/journals/lanin…

New research Article: Hospital-treated infectious diseases and the risk of #dementia: a large, multicohort, observational study with a replication cohort 🇫🇮🇬🇧 thelancet.com/journals/lanin…

What causes dementia? 2 studies using retrospective cohort data find that risk of developing #dementia increases after having a serious #infection. What does this mean for #LongCovid? The Lancet Infectious Diseases bit.ly/3e9ytZV The Lancet Healthy Longevity bit.ly/2VzObXS

If anti-amyloid drugs do not prevent clinical dementia, what are the alternatives? This paper identifies 15 new protein targets for #dementia drug development. #Whitehall study #ARIC study @jlindbohm @gill_livingston @gottesman_lab alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…

Observational evidence suggests: –#Obesity decreases disease-free years much more than longevity. –The proportion of #multimorbidity by age 75 in people with healthy weight was reached already by age 55 in those with obesity. #multicohort #UKBiobank thelancet.com/journals/landi…

This massive study combined evidence for the link between autoimmune diseases and dementia using 6 different big-data approaches. The work was lead by @jlindbohm and Nina Mars with contributions from @pyrysipila, Heiko Runz, Gill Livingston, Ramnik Xavier and many others

#OriginalResearch: In this multicohort study, hospital-treated infections associated w/ significant increase in short-term risk and modest long-term risk of major CVD events. Mika Kivimaki @nellimarikki@PyrySipila #AHAJournals ahajrnls.org/40oqjCY

#ICYMI: Severe Infection and Cardiovascular Disease Pyry Sipilä Mika Kivimaki UK Biobank Wellcome #AHAJournals

Predicting long-term risk of #dementia for cognitively healthy individuals is challenging. Error rates are very high even with the risk scores currently used in research and health care. Gill Livingston Epi of Ageing Pyry Sipilä jamanetwork.com/journals/jaman…

Proud of PhD student Leon Hirvelä from our department, whose paper about broad eating disorder symptoms and alcohol problems was published on Friday. onlinelibrary.wiley.com/doi/10.1002/ea…

Proteomics identifies potential immunological drivers of postinfection brain atrophy and cognitive decline nature.com/articles/s4358…

Association of LEAF-Q and EDE-QS scores with cholesterol levels in Finnish female athletes bmjopensem.bmj.com/content/10/3/e…

A study finds that eating disorder patients with type 1 diabetes receive hospital treatment for their eating disorder less often than those eating disorder patients who do not have diabetes. link.springer.com/article/10.100…