Congrats to Jessica Kenison-White and Niko Stevens for this excellent review on the therapeutic induction of antigen-specific immune tolerance out today Nature Rev Immunol! nature.com/articles/s4157…

Thanks for the kind words Joon-Hyuk Lee! bwhclinicalandresearchnews.org/2024/02/01/men…

Congratulations to Hong-Gyun Lee for his study out today in nature! We describe epigenetic memory in ACLY+p300+ astrocytes that worsens MS pathology nature.com/articles/s4158…

Nature research paper: Disease-associated astrocyte epigenetic memory promotes CNS pathology go.nature.com/3Tp21q7

Congrats to Michael Kilian for making the cover of Science Immunology! This exciting story on NK cell-mediated lysis of activated T cells via B7H6 proposes a potential checkpoint mechanism for cancer immunotherapies

Great paper identifying a mechanism of inflammation-induced neurodegeneration in MS! Check out the preview written by Hong-Gyun Lee doi.org/10.1016/j.molc…

Yearly lab race: complete! Quintana lab rats zoomed through the RACE Cancer Foundation 5K yesterday, with an unlikely winner taking the first place 🏆 Next up - lab olympics?

Host-gut microbiota crosstalk predicts neuroinflammation - A quick read News and Views by Fran Quintana Lab. nature.com/articles/s4156…

Our Nature Protocol for SPEAC-seq is out today! Hoping to see more labs implement this scalable platform for functional CRISPR screening of cell-cell interactions Camilo nature.com/articles/s4159…

#NewNProt describing a #microfluidic-based platform to study #cellcellinteractions bit.ly/4eM1WG4 Fran Quintana Lab

Today we all dressed up as our favorite and most consistently dressed scientist: Hong-Gyun Lee Happy Hongloween! 🎃👻

A tour de force review of the connections between the nervous and immune systems nature nature.com/articles/s4158… Fran Quintana Lab

Our study on the protective role of CLEC16A in astrocytes in MS is out today in Nature Neuroscience! Congrats to Atsushi and all collaborators! nature.com/articles/s4159…

A genome-wide CRISPR screen for regulators of astrocyte inflammation identified CLEC16A, linked to MS susceptibility, as a suppressor of NF-κB signaling; CLEC16A promotes mitophagy, and ablating it in astrocytes worsens pathology in an MS model nature.com/articles/s4159…

New review on our all-time favorite molecule out today in Nature Reviews Drug Discovery by Carolina Manganeli Polonio!

Nature research paper: Psychedelic control of neuroimmune interactions governing fear go.nature.com/4izW8kH

Our study on glioblastoma-associated immunoregulatory astrocytes is out in nature today by Camilo! We identified GBM-derived IL-11 as a regulator of TRAIL+ astrocytes, which limit anti-tumor T cell responses via apoptosis. nature.com/articles/s4158…

Therapeutic B cell depletion identifies immunoregulatory networks preview Journal of Clinical Investigation Fran Quintana Lab Carolina Manganeli Polonio jci.org/articles/view/… article David Hafler Pierre-Paul Axisa jci.org/articles/view/…

New pre-print from our lab here: biorxiv.org/content/10.110…

Our newest paper studying immunosuppressive astrocyte-GBM interactions using RABID-seq is out in nature today! Congrats to Brian Andersen and Camilo! nature.com/articles/s4158…