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Thanks to hours of work by independent angio and viability core labs, a carefully designed analysis plan and our dedicated team, we now have answers to many remaining questions about REVIVED! Join us at #EuroPCR and/or read the paper in #JACC on Wednesday 15th May.

Come and join us this morning at 'Randomised trials: substudies and extended follow up' for the REVIVED completeness of revasc presentation by Margaret McEntegart Theatre Havane from 8.30am 🚨 JACC Journals Divaka Perera

#EuroPCR #JACC LBCT SimPub: Insights from #REVIVED-BCIS2 trial - Completeness of #revascularization, whether anatomical or viability-guided, does not influence outcomes in patients with ischemic #cardiomyopathy. bit.ly/44JRcV0 Saad Ezad Margaret McEntegart Cardiac Research

JACC Journals Saad Ezad Margaret McEntegart Cardiac Research We have to challenge dogma and firmly held views with data. REVIVED surprised us all. Severe disease. Extensive revasc. Struggling to find benefit for patients. More trials underway..@JJheart_doc Harriette Van Spall, MD MPH 🇨🇦 Divaka Perera Elmir Omerovic Margaret McEntegart Roxanna Mehran

Join us this Friday 30th at the #ESCCongress for the final piece of the REVIVED puzzle! 🧩 ➡️ How ischaemic were the patients enrolled in REVIVED? ➡️ Did ischaemic burden identify patients most likely to benefit from PCI? 12:15pm @ Science Box 4!

ESC guidelines for PCI in severe LV impairment changed from 2a LoE C (should be done in most patients, based on consensus) to 2b LoE B (may be done in selected patients, based on randomised data).#ESCCongress 🙏🏽REVIVED investigators for providing the supporting evidence

Fantastic today that 2 landmark RCTs our centre University Hospitals Dorset NHS Foundation Trust recruited patients for impacted ESC guidelines to direct future care: OCTOBER Trial pushing IC imaging toward 1A REVIVED shifting PCI in ICM down to 2bB Great CI leadership Niels R. Holm & Divaka Perera #researchwin🏆

Ischemia analysis of REVIVED #ESCCongress 💜 approx 20% of LV scarred 30% ischemic on CMR 🏥 very high rates of death or aborted sudden death 📈 amount of ischemia not associated with risk of events 📈 no benefit of PCI whether ischemia extensive or mild/moderate

How do we reconcile STICH and REVIVED? Would CABG offer survival benefit with contemporary medical therapy? ➡️ Answers at late breaking science session #ESCCongress2024 this morning! Results from the first pooled individual patient level analyses from these two RCTs

Fascinating talks using pooled data from REVIVED (R) + STICH (S) ➡️ R patients had higher baseline surgical risk ➡️ No difference in tx effect in either trial by surgical risk ➡️ S-OMT arm had worse outcomes than R-OMT ➡️ R-OMT arm had better outcomes than S-CABG! #ESCCongress

Deep dive into completeness of revascularisation in REVIVED, ISCHEMIA and other trials OPCI by Divaka Perera Dr. Jeffrey W. Moses David J. Cohen, MD, MSc Ziad Ali and Paul Sapia. 🎬 opci.live/opci-lives/rev… 📖 JACC Journals bit.ly/44JRcV0 Cardiovascular and Metabolic Medicine & Sciences National Institute for Health and Care Research BCIS

Does ischaemia predict clinical outcomes and response to PCI? 📣 breaking data from REVIVED in @EHJ_ed today 🚨 Patients had extensive ischaemia (mean 31% of LV) and scar (mean 18% of LV) 🚨 Ischaemic burden did NOT predict outcomes, or response to PCI academic.oup.com/eurheartj/arti…

Still more evidence that ischaemia doesn’t identify stable CAD patients who benefit from revascularisation: #ISCHEMIA trial and now REVIVED ❓do plaque events relate to total atheroma burden more than critical lesions ❓is arrhythmia driven by scar more than ischaemia

‼️Ischaemia does not predict prognosis or response to PCI 📣patients enrolled in REVIVED had LVEF<35% extensive ischaemia and scar++ Paper by Holly Amedeo Chiribiri Divaka Perera et al out in EHJ Editor-in-Chief European Society of Cardiology Journals today British Heart Foundation National Institute for Health and Care Research doi.org/10.1093/eurhea…

📢 Exciting milestone! Guy’s and St Thomas’ NHS Foundation Trust has now randomised its 1st and 2nd participants, bringing us to 3 randomisations study-wide! 🎉 Huge thanks to the St Thomas' Hospital team for their hard work and commitment to research! Divaka Perera #BCIS4 #GSTT

Survival better with current medical+ device therapy than STICH-era MT (+/- CABG) if LVEF<35%! ➡️ are lessons from all RCTs with a OMT control arm time-limited? ➡️ is PCI better than CABG (or vice versa)? These two trials can’t answer this. Await STICH3 trials BCIS-4 Trial