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Missed #IAS2023? Dr Ming Lee and colleagues discuss #RIOtrial and other exciting updates from the cobference, available on the STI_BMJ podcast now! 🔊 stibmj.podbean.com/e/ias23-confer…

We're delighted to welcome the latest site offering the RIO study, based at the Churchill Hospital CCVTM in Oxford, bringing the total number of study sites to 12!

Prof Sarah Fidler gives an update on treatment interruption trials at #EACS2023

Check out these eposters at #EACS2023 EP.A.061 attitude towards participation in cure trials which include a TI EP.A.110 The impact of TIs on viral resuppression EP.B2.042 Comparing CVS risk models in people living with HIV on modern ART.

🎙️vimeo.com/877037653/739f… 🎙️ Johan, who is currently participating in the #RIOtrial, kindly agreed to share his experiences and feelings with Prof. Sarah Fidler about pausing antiretroviral therapy (ART) as part of the trial. Watch the #ParticipantInterview now ⬆️

People living with HIV were surveyed on their views on joining studies like #RIOtrial which involving temporarily stopping ART (also known as ATIs). Read the paper by members of the RIO and HEATHER studies here! 🔽

vimeo.com/886495898/2bb0… Watch Prof Sarah Fidler speak to Ms Louise Terry, a research nurse working on the #RIOtrial, to find out what's it like working on the study.

Dr Amanda Clarke and Caroline Cable from @BSUHresearch share their experiences working on the #RIOtrial. University Hospitals Sussex is one of our 12 clinical sites participating in the study! To watch and find out more, visit riotrial.org 🌟💫

frontiersin.org/journals/immun… PennyZach John Frater Nuffield Department of Medicine report that 29% of a UK cohort of people treated in PHI had predicted resistance to 10-1074 by single genome Env sequence prediction algorithm. This highlights the need for bNAb resistance screening in clinical trials.

▶️ Watch a free replay of our latest #webinar, "Analytical treatment interruptions in #HIV cure research", featuring IAS President Sharon Lewin, IAS Governing Council member Josephine Nabukenya, Prof. Thumbi Ndung'u, Jillian Lau & other leading voices! plus.iasociety.org/webcasts/analy…

sarah fidler from Imperial College London starts her talk abt Key Partnerships for #HIVcure research w/ a primer on the contexts & challenges of cure trials, including interrupting treatment in a study. Sarah is such a clear and articulate speaker, always a joy to watch #AIDS2024

More #HIVcure posters at #AIDS2024 #bNAb sensitivity testing in the RIOtrial of long-acting 3BNC-117 and 10-1074 in PLWHIV started on ART in acute infection. Proviral DNA on ART and plasma RNA at time of viral rebound was tested using NIH or Rockerfeller models.

#AIDS2024 PennyZach and Ming Lee present their poster comparing #BNAB sensitivity prediction outcomes using blood or gut proviral DNA and rebound plasma RNA in people treated during primary HIV infection.

onlinelibrary.wiley.com/doi/epdf/10.10… Pleased to see our meta-analysis of the impact of ATIs and trial interventions eg. #bNAbs, on time to viral resuppression after restarting ART in cure-related studies. Shoutout to my student Miles Eason Imperial Medicine, who drove this work & data collection

onlinelibrary.wiley.com/doi/10.1002/ej… Check out this paper by RIO researcher Timothy Tipoe from John Frater lab Nuffield Department of Medicine. He reports how HIV-specific T cell responses in people with HIV are impacted by ATIs.

It's a celebratory #RIOtrial participant feedback meeting today! As Prof sarah fidler explains, recruitment has completed and we are closer to being able to report the first findings of the study by early next year.

Prof John Frater Nuffield Department of Medicine completing the laboratory journey of the participants' samples, and how we can analyse virology and immunology data in depth from these samples.

Next up is Simon Collins HIV i-Base who we're very privileged to have been part of the study from the very beginning as a community representative, sharing his insights on the importance of the study as well as community impact towards the study.