🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Job alert: I am hiring a Program Manager / Postdoc to manage and grow the ACTG: American Campus Tree Genomes project and others. In-person HudsonAlpha preferred, but remote possible. ACTG story: shorturl.at/gGX13 Apply here: shorturl.at/jBPVZ

We’re looking for a postdoc shared with Oliver Stegle. Join us: design ambitious multi-sample single-cell experiments in developing embryos, model temporal response patterns, test predictions. Open to different backgrounds and expertise. If you’re interested, get in touch soon!

Drumroll please…. We have JUST POSTED a mind-boggling set of 37 community mini-symposia and workshops! Proposed BY the community and organized BY the community! Check it out! (I’ll input session chairs tomorrow! I ran out of steam tonight… ) icar2024.weebly.com/mini-symposiaw…

An intron library of over 140,000 variants reveals sequence features that impact splicing efficiency in yeast. #intron #splicing bit.ly/496GXv1

Structural variants (SV) impact more nucleotides per human genome than other forms of genetic variation. To better understand SV impact, we developed a method to 'shuffle' mammalian genomes and characterize them with single-cell resolution in a pool. biorxiv.org/content/10.110…

Plant enhancers exhibit both cooperative and additive interactions among their functional elements (Tobias Jores, Jackson Tonnies, Nicholas A Mueth, Andrés Romanowski, Stanley Fields, Josh T Cuperus, Christine Queitsch) buff.ly/3vlf2t0 Josh Cuperus ASPB #PlantSci

Check out our new work!

Josh Cuperus- Univ of Washington-Seattle, Josh Cuperus is organizing the "Chromatin at Single-cell & Single-molecule Resolution" session at #ICAR2024SanDiego. Submit your abstract by 15 April. See session description (#7) here- icar2024.weebly.com/mini-symposiaw…

IN BRIEF: Dissecting and redesigning enhancers of photosynthesis genes (Peng Liu) buff.ly/49TCLyH Josh Cuperus ASPB #PlantSci

Please join us for a tribute symposium on May 17 to Philip Benfey, a luminary in plant biology. Details and Zoom link here: as.nyu.edu/departments/bi…

I understand imitation is the sincerest form of flattery, but as junior faculty it is frustrating when Oxford Nanopore copies the figures of your work verbatim without any credit. youtube.com/watch?v=1NkBr3… Figure 1: biorxiv.org/content/10.110… Figure 4: biorxiv.org/content/10.110…

I'm thrilled to announce the complete program for #ICAR2024SanDiego! 👉🏽Please check out the amazing line of up over 300 speakers in nearly 50 sessions! I hope to see you soon in San Diego.. icar2024.weebly.com/full-program.h…

Thrilled to present our collaboration w/ Stergachis Lab members “The regulatory potential of transposable elements in maize”. Single-molecule Fiber-seq - accurate and sensitive accessibility in maize. New open chromatin regions in LTRs and much more! biorxiv.org/cgi/content/sh…

Climate change be damned! Out in Nature Communications, we interrogated over 54k plant terminator sequences to synthetically design robust terminators for crop engineering. tinyurl.com/d63n894r

Are CpG methylation and chromatin accessibility polar opposites? #Fiberseq proves they are not in #maize – transposon enhancers can have simultaneous single-molecule hyper-mCpG AND chromatin accessibility. Wonderful collaboration w/ Queitsch lab & Josh Cuperus biorxiv.org/content/10.110…

Excited to share our latest work investigating the consequences of extant genetic variation in cis-regulatory elements at single-cell resolution. A short 🧵 biorxiv.org/content/10.110…

Out now on biorxiv: We studied the activity of enhancer-blocking insulators in plants and found that they also act as silencers when placed upstream of moderate to weak enhancers. biorxiv.org/cgi/content/sh…

Our lab is looking for a postdoc UW Genome Sciences/University of Washington/ISCRM at UW! We tackle a wide range of biological Qs from cell-specific responses to perturbation to molecular consequences of aging. We also work hard on new #TeamMassSpec methods to scale the # of proteomics samples we can analyze.

New preprint! An atlas of conserved TF binding sites across flowering plants generated with multiplexed DAP-seq. When integrated with multi-species snRNA- and snATAC-seq reveals how TF activity shapes development and stress responses at the cellular level.biorxiv.org/cgi/content/sh…

nature.com/articles/s4147…