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Interested in a novel method for modification-free protein-drug interactions deconvolution in lysate and intact cells? Check out our new article combining Ion-based protein precipitation with LC-MS/MS creating IPP and I-PISA. pubs.acs.org/doi/10.1021/ac…

Check out our recent collaborative work with Prof. Rikard Holmdahl's team, on redox regulation of PTPN22 in autoimmune diseases: elifesciences.org/articles/74549

Do you know isoaspartate acts as a molecular clock in aging? We collaborated with Prof. Charlotte Teunissen and Dr. Guo to test the link between isoaspartate and Alzheimer's disease etiology on A&D journal doi.org/10.1002/alz.12… Alzheimer's & Dementia Journals Alzheimer's Association ISTAART

In our new preprint, we identify the O-glycosylated substrates of GALNT1 using versatile proteomics tools. Arguably one of the most challenging PTMs to study. We close in on a motif too.

The Omnitrap – IMS platform has successfully been installed at KI! Thank you Fasmatech , MSvision and RZLab for the great effort. Time to produce some exciting data!

Individual amino acid isotopic ratio measurement and peptide sequencing using only 1 μg of sample, all in one!

Finally, all pieces have been put together! The #FTMS Booster is now installed in the RZLab. Thank you Spectroswiss for all the help and also for a great talk!

Happy Sunday 🙂 Please check out our new protocol - "Proteome Integral Solubility Alteration (PISA) Assay in Mammalian Cells for Deep, High-Confidence, and High-Throughput Target Deconvolution". bio-protocol.org/e4556 RZLab Xuepei Zhang #proteomics #spectrometry #cells

New work from our lab at Karolinska Institutet uncovers massive solubility changes of neuronal proteins upon simulation of traumatic brain injury. #TBI #neuroscience #proteomics #TeamMassSpec

DOPA is just as good (or even better!) than Vitamin C - when it comes to protecting tissues from free radicals. 🛡️🔥 Proud of this largely experimental (!) work of our lab. 🎉🎉🎉 Thanks to amazing collaborators Tobias Dick RZLab The Prisner EPR Group and others!

Our new collaborative study shows that NCF1-dependent production of ROS protects against lupus by regulating plasmacytoid dendritic cell (pDC) development and functions. ROS deficiency enhances pDC generation through the AKT/mTOR pathway. insight.jci.org/articles/view/…

This toy example may change how you look at tSNE & UMAP. They find clusters in the most uniform data possible.

Check out our new work on PISA-REX for analysis of proteomes in the three dimensions of redox state, solubility and expression for target identification.

New paper published. Hopefully our results will lead to developing novel biomarkers and therapeutic interventions against traumatic brain injury in the long run.

Peptide sequencing based on host–guest interaction-assisted nanopore sensing - Nature Methods nature.com/articles/s4159… --- #proteomics #prot-paper