Ryan Zarychanski (@rzarychanski) 's Twitter Profile
Ryan Zarychanski

@rzarychanski

Professor, Hematology/Critical Care. Clinician-Scientist studying hematologic consequences of critical illness.

ID: 3164631949

calendar_today20-04-2015 00:46:02

375 Tweet

793 Followers

90 Following

Vinay Prasad MD MPH (@vprasadmdmph) 's Twitter Profile Photo

Disgusting, unethical PLACEBO control trial in colon cancer just so Fruquitinib can win I will show you that placebo should not have been the control arm, & the IRBs & FDA failed 🧵 First, this trial tests a new drug vs. placebo (sugar pill) in patients dying of colon cancer

Disgusting, unethical PLACEBO control trial in colon cancer just so Fruquitinib can win

I will show you that placebo should not have been the control arm, & the IRBs & FDA failed 🧵

First, this trial tests a new drug vs. placebo (sugar pill) in patients dying of colon cancer
Ryan Zarychanski (@rzarychanski) 's Twitter Profile Photo

All are welcome! Incredible privilege to have Dr. Middeldorp in Winnipeg, Canada to deliver the Lyonel G Israels Memorial Lecture. Please join us in person, or virtually, from wherever you are. Saskia Middeldorp ISTH CanVECTOR Network INVENT-VTE U of M Rady Faculty SOGC ASH

Matthew D. Neal, MD (@macky_neal) 's Twitter Profile Photo

Brilliant talk by my friend Ryan Zarychanski on the role of adaptive clinical trials and assessing heterogeneity of treatment effect on #immunothrombosis #ISTH2023 ISTH

Brilliant talk by my friend <a href="/RZarychanski/">Ryan Zarychanski</a> on the role of adaptive clinical trials and assessing heterogeneity of treatment effect on #immunothrombosis #ISTH2023 <a href="/isth/">ISTH</a>
Ryan Zarychanski (@rzarychanski) 's Twitter Profile Photo

Wonderful presentation by Manitoba’s own Quinn Tays at the International Society on Thrombosis and Haemoatasis Congress in Montreal - if therapeutic heparin is started for Covid on the ward, reduce the dose to prophylaxis if the patient requires ICU-level care

Ryan Zarychanski (@rzarychanski) 's Twitter Profile Photo

It’s time to design and conduct trials differently than we have in the past so we can detect heterogenous treatment effects and identify patients who will benefit or be harmed! remap-cap U of M Rady Faculty CancerCare Manitoba @ATTACC_COVID

Ryan Zarychanski (@rzarychanski) 's Twitter Profile Photo

Thank you! Just as medical treatments have evolved, so have randomized trials. The next generation of trials will need to designed to detect and quantify heterogenous treatment effects (HTE) so that we can identify patients who benefit or may be harmed. Enough negative trials -

Ryan Zarychanski (@rzarychanski) 's Twitter Profile Photo

UM’s College of Pharmacy student is doing a superb job presenting the impact of symptom duration prior to hospitalization on clinical outcomes in Covid and whether symptom duration impacts the treatment effect of therapeutic-dose heparin. Well done Quinn! ISTH U of M Rady Faculty

UM’s College of Pharmacy student is doing a superb job presenting the impact of symptom duration prior to hospitalization on clinical outcomes in Covid and whether symptom duration impacts the treatment effect of therapeutic-dose heparin.  Well done Quinn! <a href="/ISTH/">ISTH</a> <a href="/UM_RadyFHS/">U of M Rady Faculty</a>
CALL TO ACTIVISM (@calltoactivism) 's Twitter Profile Photo

There was a little coffee shop where two people arrived and approached the counter. “Five coffees ☕️ please. Two for us and three pending.” They paid, they took their two coffees and left. I asked the waiter. "What’s this about pending coffees?" “Wait and you'll see." Some

There was a little coffee shop where two people arrived and approached the counter.

“Five coffees ☕️ please. Two for us and three pending.” 

They paid, they took their two coffees and left.

I asked the waiter. "What’s this about pending coffees?"

“Wait and you'll see."

Some
Ryan Zarychanski (@rzarychanski) 's Twitter Profile Photo

Do not miss! - Only 2 more days to Saskia Middeldorp. Join virtually or in person. ISTH #ISTH2023 INVENT-VTE European Hematology Association ASH Find out the latest data! Hear about patience, persistence, collaboration, and passion to improve thrombotic maternal-fetal outcomes.

Ryan Zarychanski (@rzarychanski) 's Twitter Profile Photo

Excited & privileged to receive funding from Research Manitoba to create skilled jobs, build clinical trial expertise in Manitoba, and provide mentoring opportunities for new researchers - all while improving outcomes for patients with pneumonia! CancerCare Manitoba U of M Rady Faculty

Ryan Zarychanski (@rzarychanski) 's Twitter Profile Photo

Spectacular field trip hiking the Hunt Lake trail with Saskia Middeldorp and Winnipeg colleagues - work hard; play hard, while making memories and friendships together. What a day!!!

Ryan Zarychanski (@rzarychanski) 's Twitter Profile Photo

Inspiring Lyonel G Israels Memorial lecture and special session on women leaders in medicine by Dr. Saskia Middeldorp - she won the heart of every Winnipeg’er who attended. What an enormous impact in such a short amount of time. Thank you Saskia!

Ryan Zarychanski (@rzarychanski) 's Twitter Profile Photo

Congratulations Deborah & team. This trial needed be done for years and you figured out how to get it done in a way that compels us all to change practice. Use smaller tubes; take less blood; reduce transfusion, especially at a strained system level. Amazing!