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It’s BioPOD season 2! Our new episode “When DNA met Sall4” is OUT NOW! buzzsprout.com/286788/9465858 @JackTSuitor talks to Raphaël Pantier and Kashyap Chhatbar of the Bird lab about how Sall4 binding to AT rich DNA affects #GeneExpression and enables #differentiation. @WTcell @edincell

Glad to see our latest study LifeScienceAlliance in collaboration with Atlanta Cook (@WTcell). We describe the structure of SALL4 zinc-fingers (ZFC4) with AT-rich DNA and demonstrate that disease-causing mutations disrupt DNA binding. Kashyap Chhatbar BeaKez life-science-alliance.org/content/6/3/e2…

See new structural analysis by Watson et al. of SALL4, important for ESC maintenance. They show its interactions with AT-rich DNA and how previously uncharacterised Okihiro patient mutations affect DNA binding. @WTcell Kashyap Chhatbar life-science-alliance.org/content/6/3/e2…

Want to visualise ALL AlphaMissense predictions? huggingface.co/spaces/kashyap…

Research assistant/lab manager position open in Adrian Bird’s lab. Come and join us! elxw.fa.em3.oraclecloud.com/hcmUI/Candidat…

“cBAF generates subnucleosomes that expand OCT4 binding and function beyond DNA motifs at enhancers.” Amazing story by GERARD Matthieu Marina Nocente. Congrats to all the authors. nature.com/articles/s4159…

Happy to share two post-doc papers co-authored with the amazing Ana Monteagudo-Sánchez and Teresa Urli. We had amazing collaborators for both projects, even our supervisor Maxim Greenberg joined in on the experimenting! 1: pubmed.ncbi.nlm.nih.gov/39180406/ 2: rdcu.be/dXXqh

Analyzing whole genome DNA methylation data? Our new method MethyLasso is out in NAR! It can help you identify regions with low or partial methylation (LMR, UMR, DMV, PMD, PMD) or differentially methylated regions (DMR) and was benchmarked against others doi.org/10.1093/nar/gk…

Pleasure to continue our collaboration with Marcus D Wilson and group and play a small part in this study which is now out in the paper version. Read on to learn more about DNMT3A's interaction with H3K36me2 and H2AK119Ub modified nucleosomes: embopress.org/doi/full/10.10… #epigenetics

Just a few days left to apply! Join the RNA Dynamics in Cancer group CRUK Manchester Institute as a Postdoc!