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For storage, I’m freeze drying most of my cells rather than storing in a -80c. Can have em at room temperature with full stability for decades. Way less energy use and I don’t need to worry about power turning off or freezers breaking

Biggest medical discoveries of the week (🧵) 1/8 A twice-yearly prophylactic injection - Lenacapavir - is >95% effective to prevent HIV (in men - it's already proven in women!) It's even more effective than daily pills (F/TDF), due to better adherence nejm.org/doi/full/10.10…

New preprint from the lab where we show how dysregulated transcription elongation causes neurodevelopmental defects. Immensely proud of Hedda Somsen and the entire team! biorxiv.org/content/10.110…

Congratulations and welcome to our new Young Investigators!

5 big medical advances from November (🧵) 1. Diabetes prevention In obese adults, Tirzepatide (a GLP1/GIP receptor agonist) was >90% effective to prevent type 2 diabetes Analysing only those fully compliant to 15 mg Tirzepatide, its efficacy was 100% nejm.org/doi/full/10.10…

If the structural similarity between hemoglobin and chlorophyll doesn't fascinate you, then I'm not sure we can be friends.

Trump says RFK Jr will “investigate” the link between vaccines and autisms as “somebody needs to find out.” We’ve ALREADY FOUND OUT - >600,000 kids in Denmark - >90,000 in the US - >1.2m kids worldwide NO LINK. How many more of these does he want us to do?

It's wonderful to see that spatial proteomics has been recognized as Nature Methods' Method of the Year 2024. nature.com/articles/s4159…

🧬GWAS is fundamental in drug discovery, linking disease to genetic variants. However, studying rare and uncommon diseases with GWAS is hard due to the huge sample sizes required. How can we use AI to help GWAS with small cohorts? In a multi-year collaboration GSK

Biggest medical discoveries of the week (🧵) 1/8 Treating pre-eclampsia by sprouting new blood vessels Delivering VEGF to the placenta (intravenously, via placenta-tropic mRNA nanoparticles) resolved high blood pressure and birth weight (in mice!) nature.com/articles/s4158…

2024's top 10 advances in medicine (🧵) 1. The numerous benefits of GLP1R agonists As well as causing weight loss, GLP1s can prevent complications of obesity (diabetes, liver fibrosis, kidney disease, osteoarthritis), treat heart failure, and even slow down Parkinson's:

One of the remarkable things for me about NeurIPS this year was how quickly the entire AI for Biology community has gone all-in on biological foundation models. Virtual cell models will enable us to predict how cell states will change in response to chemical perturbations.

Our preprint by Domenic Narducci and the companion preprint by deWitLab are now out in Molecular Cell ZNF143 is not a general looping factor and was identified as such due to a non-specific antibody. Instead it is TF with the longest residence time measured (to our knowledge)

Which are the highest cited original research publications in #PancreaticCancer over the past five years (from 2020 to 2024 end)? All metrics obtained from Google Scholar (caveat: GS tends to OVERESTIMATE citations but the trends are consistent overall). 🧵 Below:

Happy new year, this paper just made it for 2024. Thanks to hard efforts of all in the lab. A new way to select clones for generating TCR transgenic mice, no cloning involved doi.org/10.7554/eLife.… eLife - the journal

WHY DOES THE EPIGENETIC CLOCK TICK? While money has been poured into developing therapies to reverse the epigenetic clock (Altos Labs 🤑), why the epigenome changes with age at all is unclear. In Nature Aging today, we suggest a potential driver: somatic mutations.

Top 5 advances in medicine this week (🧵) 1. AI-designed snake anti-venoms These inhibit the 'three-finger toxins' that make the venom of snakes like cobras and mambas lethal - cheaper, with higher affinity and more scalability than current therapies nature.com/articles/s4158…

HEK293 cells are an immortal ( forever living) cells from an embryonic kidney made in 1973. These immortal cells (not fetal tissue or baby parts) have been the corner stone of drug discovery in biomedicine- everything from cancer to Alzheimer’s. American scientists are people

It's clear that many do not understand what NIH-funded research does to improve health. It's time to revive a study published 10 years ago that provides incredible information about this. link in the comment Every single new drug approved by the FDA from 2010–2016 was built on

The aluminum question: why the route of exposure matters less than you might think Aluminum in vaccines worries a lot of people. The word sounds industrial, not medical. I get that. Yet aluminum-based adjuvants have been part of routine immunization for over 90 years, and the