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Now out in NDT Endothelial to mesenchymal transition in kidney fibrosis by ton rabelink et al. academic.oup.com/ndt/advance-ar…

Our latest preprint and a long time in the making, full of amazing images and novel findings, we spatiotemporally map kidney innervation from embryo to adult! Pierre-Emmannuel N’Guetta Sarah R. McLarnon biorxiv.org/content/10.110…

These five minutes are worth more than many hours of AI alarmist talk.

Dr. Nikolche Gjorevski and colleagues at Roche show that patient-derived intestinal organoids and tumoroids supplemented with immune cells can be used to study the on-target off-tumor #toxicities of T cell-engaging bispecific antibodies. go.nature.com/3vrxCiL

reNEW researchers in the LUMC Leiden have established an in-house platform to produce #GMP-compliant #hiPSCs. The platform is a key milestone as it allows the production of hiPSC derived cell therapy products developed in reNEW for clinical purposes. sciencedirect.com/science/articl…

reNEW (reNEW) scientists from LUMC Leiden developed and validated a platform for generating GMP-compliant hiPSC lines. 🧫 The platform entails the methodology for donor recruitment, donor material procurement, hiPSCs manufacture, and more. bit.ly/4adfOqw

International consensus statement published in Nature Reviews Nephrology calls for urgent action to address CKD on the global public health agenda. Read “Chronic Kidney Disease and the Global Public Health Agenda: An International Consensus” ➡️ doi.org/10.1038/s41581…

Using spatial metabolic flux we identified the conditions to preserve discarded human donor kidney’s for at least 4 days ex vivo. Such an approach also holds the potential for resuscitation and could increase the window for organ allocation. rdcu.be/dHL6W

New work from the ton rabelink lab shows that a cell-free nutrient-supplemented perfusate allows 4-day ex-vivo preservation of human kidneys using spatially resolved lipidomics and metabolomics, LUMC Leiden, reNEW nature.com/articles/s4146….

Researchers have mapped a tiny piece of the human brain in astonishing detail go.nature.com/4anVZN5

Presented at #ERA24: In this phase 2 randomized trial, the CD38 monoclonal antibody felzartamab showed acceptable safety and promising efficacy among patients with chronic antibody-mediated kidney-transplant rejection. Read the full trial results: nej.md/4dHQhsa

COL4A3 and COL4A4 pathogenic variants in the normal population: redefining Alport syndrome? By Judy Savige ✏️Vaibhav Tiwari #ERA24 #SoMe team 💥Time to change from Alport syndrome to Alport spectrum!! ⚡️ XL- kidney failure in males and 20% of females by the age of 60 ⚡️ AR-kidney

Terrific Nature paper that will greatly improve the analysis of spatial transcriptomic data! Working on this as an editorial advisor was a blast, and more publications are coming! I'm sure Katalin Susztak Ben Humphreys will like it, as well as 10x Genomics nature.com/articles/s4158…

Latest in our Plasticity Project, featuring our fave cells, Primitive Endoderm (PrE), and their in vitro model, nEnd. Amazing PhD journey @MLAgerhom, contributors AnnikaCharlotte alboo Marta Perera Martin Proks Teresa Knudsen Manzanares lab (1/11). twtr.to/FfAst

Nature research paper: Bridge RNAs direct programmable recombination of target and donor DNA go.nature.com/3VDSJb3

Niels Geijsen and Frank Staal are part of a project aiming to transform Cell and Gene Therapies. The project has been awarded €10M through the IPCEI Med4Health program and is a collaborative effort between NecstGen , NTrans Technologies, LUMC Leiden and Divvly.

Up to 60% of the human adult body is water. However, in tissue this water is bound and associated for a big part to the polysaccharide Hyaluronan. This gel-like component of tissue is critical to tissue repair development rdcu.be/dR9WX Nature Reviews Nephrology reNEW

World-first breakthrough! reNEW Melbourne researchers at @MCRI have created lab-grown blood stem cells resembling those in the human body. This could pave the way towards personalised treatments for blood diseases such as leukemia & bone marrow failure. 🔗 nature.com/articles/s4158…

Another Resource developed by Josh Brickman and colleagues presents a reference tool (brickman-preimplantation.streamlit.app) based on deep learning models for unbiased annotation of preimplantation embryo datasets. nature.com/articles/s4159…