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Today in bioRxiv, we describe the development of HELIX, an advance that markedly improves properties of type V-K CRISPR-associated transposases (CASTs) for programmable, cut-and-paste, multi-kilobase DNA integration. 1/14 🧵👇 biorxiv.org/content/10.110…

1/1 "SpRYgest, takes the die out of digest" - Rachel Silverstein We recently repurposed our PAMless Cas9 enzyme SpRY for in vitro DNA digests (so-called “SpRYgests”), as a substitute to overcome the limitations of restriction enzymes . A 🧵: biorxiv.org/content/10.110…

Celebrating my #scoopanniversary with a scoop of 🍦! 1y ago my PhD project got scooped and I remember wishing I could just fast-forward time. So here we are now! My paper did get published in the end and I moved to Boston, to start a PostDoc in an amazing Lab 🧬! 👇(1/5)

1.Excited to share our 1⃣ bioRxiv of 23 on the optimization of base editing as a genetic treatment for spinal muscular atrophy (#SMA). We demonstrate the versatility, efficacy, and safety of #baseeditors in SMA cells and in vivo in SMA mice. biorxiv.org/content/10.110…

Today in bioRxiv, we introduce Click Editing - which combines DNA-dependent polymerases, HUH endonucleases, and RNA-programmable nickases for versatile human genome editing without double-strand breaks. Co-led with Joana Ferreira da Silva 🤝🧬 (1/15) biorxiv.org/content/10.110…

Today in @bioRxiv, we describe Click Editors (CEs) which combine DNA-dependent DNA polymerases, HUH endonucleases and RNA-programmable nickases for versatile genome editing without double-strand breaks 🧬. A study co-led with Connor Tou. A 🧵 (1/14): biorxiv.org/content/10.110…

We’re excited to share our work developing a new gene editing approach that we’re calling #clickediting 🖱️✴️🧬. Click editors (CEs) utilize DNA-dependent polymerases to write bespoke edits into the genome. biorxiv.org/content/10.110… CGM at MGH MassGeneral News @MGH_RI Harvard Medical School

Excited to share my PhD work… and more CRISPR-Cas9 PAM variants than anybody asked for