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Thrilled to share our structure of mammalian sperm microtubule doublet at ~3.5Å identified almost all MIPs (>40), out of which >15 are novel a new era for #maleinfertility biorxiv.org/content/10.110…

Essential comments, and a much needed paper. The nonsense in literature, social media (including professional sources sometimes!) and press clouds an otherwise promising and exciting technology!

🚨New paper in J. Am. Chem. Soc.! #ExpansionMicroscopy is democratizing access to #superresolution imaging, but it works best on proteins & nucleic acids. What about lipids? Some great tools have emerged, but Brittany White sought ones optimized for lipids: 1/5 pubs.acs.org/doi/10.1021/ja…

Abundant Aβ fibrils in ultracentrifugal supernatants of aqueous extracts from Alzheimer's disease brains biorxiv.org/content/10.110…. Where have all the oligomers gone?

To complete the revolution - pay the reviewers.

The first paper from my postdoc is officially out in Science, Space & Robots today! We solved the first structure of the "spike" protein for the #hepatitisC virus 🦠 (HCV) and pave the way for future HCV #vaccines 💉. Read the full story here: science.org/doi/10.1126/sc… 🥳🥳🥳🤩🤩🥰🥰

XRD-00101: MicroED dataset of Sodium Glutamate Monohydrate (Ajinomoto; MSG) xrda.pdbj.org/entry/101 0.65 Å from four best crystals :) A companion dataset of the same compound by X-ray diffraction is also available at xrda.pdbj.org/entry/94.

The 2023 #3DEM #GRC is open for applications and we are now starting to periodically review them. To improve the chances of being accepted, please provide a title and a short abstract of you poster!📜✍️🙂👍 grc.org/three-dimensio…

We added Goodsell style representation in Coot 1.0 😍 #coot #ccp4 #sciart

In collaboration with JEOL (Dr. Fukumura), we tested MicroED with Direct Electron Apollo on CRYO ARM 300. We got a wonderful 0.5 Å map of sodium glutamate monohydrate (limited by the detector distance) from 14 crystals.

We’re excited to extend noninvasive optogenetics beyond the brain to address a nearly 150-year-old question in a new study out today nature: nature.com/articles/s4158… Work led by Brian Hsueh, myself, and Karl Deisseroth, with an amazing team in the D-lab and many others!

More fluorescence #ONE images of single otoferlin* molecules (together with AuditoryNeuroscience@Goettingen Prof. Moser lab). With the new version of ONE we can hopefully fill the gap between #fluorescence microscopy and #CryoEM / Lippincott-Schwartz Lab Radu Aricescu Stefan W. Hell biorxiv.org/content/10.110…

#Democracy_in_microscopy We thank our brilliant colleagues at nature Ewen Callaway Richard Van Noorden for introducing our #ONE technology to the #public!! nature.com/articles/d4158…

Amazing and very well deserved, congratulations Ali!!!🤩

We show that GluD1 binds to GABA, an extraordinary feature for iGluRs. GluD1 activation produces long-lasting enhancement of GABAergic synaptic currents in the adult mouse through a mechanism dependent on trans-synaptic anchoring. 7/n

🥁Out on Science Magazine 👉GluD1 binds GABA and controls inhibitory plasticity 🔗science.org/doi/10.1126/sc… 👏Congratulations to Laura Piot and Paoletti Lab, and @MonyLaetitia Radu Aricescu and all authors at #IBENS and @MRC_LMB for this achievement!

The Miller lab is super proud to have published its work on GABA-A receptor α5 selective modulators, in Nature Structural and Molecular Biology! nature.com/articles/s4159…. NatureStructMolBiol Vikram Kasaragod Tomas Malinauskas Radu Aricescu Dept. of Pharmacology, Univ. Cambridge BiocEM Cambridge

Some nice structures, some poor ones too, but certainly not “time resolved”😅 Unless this is the laziest nicotinic receptor ever 🤪 😍

Happy to share our paper in NatureStructMolBiol, led by Uriel López and Lachlan Munro. We are studying how the antidepressant vortioxetine acts on serotonin 5-HT3 receptors in rodents and humans. rdcu.be/dGv49

📢We’re recruiting a Research Assistant! 🤓 📢The role involves protein engineering to better understand and control cell signalling in cancer 🧫🧪🧬. Training will be provided. Join us at CAMS Oxford Institute and Nuffield Department of Medicine! Apply here: my.corehr.com/pls/uoxrecruit…