Our first foray into (noncoding) rare variant association testing! gruyere learns functional annotation importance & finds associations missed by existing methods. Anjali Das did a fantastic job with model assessment & scaling! Joint w Towfique Raj medrxiv.org/content/10.110…

Excited to announce my new lab at MCDB Michigan opening Jan 2025! 🎉 We’ll study how cells work together to shape the GI tract, with ties to regeneration & disease. Hiring at all levels—esp. a research tech to help launch the lab! Info: huyckelab.org #DevBio #CellBio

Identification of the Polo-like kinase substrate required for homologous synapsis. New study from Ariel Gold, Yumi Kim (Yumi Kim Lab) and colleagues Johns Hopkins University: hubs.la/Q02_P8dG0 #CellCycle #CellDivision #Genetics

Thrilled to share that our preprint on the role of satellite DNA in homologous chromosome pairing is out 🎉 researchsquare.com/article/rs-553… I’m deeply grateful to my incredible co-authors, The Jagannathan Lab & everyone who provided suggestions and support 💕 Jagannathanlab.com

Excited to share our preprint: Cohort-level analysis of human de novo mutations points to drivers of clonal expansion in spermatogonia! We developed methods to uncover drivers of clonal expansions in sperm (CES) using 55k disease trios & gnomAD SNV data. medrxiv.org/content/10.110…

Today we report a compendium of human gut microbiomes with >168,000 samples We discovered distinct microbiome patterns across the globe, and show we can predict where a person lives just from their gut bacteria Now out in Cell cell.com/cell/fulltext/…

Haplotype rather than single causal variants effects contribute to regulatory gene expression associations in human myeloid cells biorxiv.org/content/10.110… #biorxiv_genomic

Things I wish more people knew about doing science in the US (thread):

I’m thrilled to share that our work on reference bias in aDNA analysis has been published in Genome Biology! This study (genomebiology.biomedcentral.com/articles/10.11…) highlights how discrepancies in small variants and other factors between T2T-CHM13 and GRCh38 impact introgression inference.

my SLiM-tools vscode extension is now published to the extension marketplace. download / install and use it all from within vscode

Based on the new DNA evidence now from Harbin, as well as Xiahe, it's now almost certain that the samples in the yellow box are all Denisovan. It's very exciting that we finally get to study the morphology of these samples in light of their relationship to us and Neanderthals.