Extremely happy to share our recent work on β-arrestins!!!!! Here we visualize the atypical interaction of βarrs with 7TMRs and also show the structural transition of the carboxyl terminus of βarr2 from a β strand to an α helix upon activation by D6R. science.org/doi/10.1126/sc…

Delighted to share our study on elucidating the molecular principles of ligand promiscuity & structural mimicry in the chemokine receptors!!! Molecular basis of ligand promiscuity, structural mimicry, and atypical dimerization in the chemokine receptors biorxiv.org/content/10.110…

Delighted to share our study on probing the conformational diversity in GPCR-beta-arrestin complexes !!! A genetically-encoded nanobody sensor reveals conformational diversity in beta-arrestins orchestrated by distinct seven transmembrane receptors biorxiv.org/content/10.110…

Delighted to share our study on niacin receptor structure & signaling-bias published in Nature Communications !! Spearheaded by our amazing team including manish, Parishmita Sarma, Ramanuj Banerjee and several other members in our laboratory IIT Kanpur !! nature.com/articles/s4146…

Grateful to have contributed to this journey of discovery. Check out the work and explore the insights here!!!!!

Delighted to share our latest study on a nanobody-based sensor of GPCR activation and signaling! A genetically encoded nanobody sensor reveals conformational diversity in β-arrestins orchestrated by distinct seven transmembrane receptors | PNAS pnas.org/doi/10.1073/pn…