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More than a strict P<5e-8 cut off, biological evidence to support the loci matters more. Here the authors show that ~92% of the 2010 BMI loci at P<5e-5 that overlapped with adipocyte promoters turned out to be genome-wide significant later in 2018. elifesciences.org/articles/62206

This is the stuff great problems are made of: Simple enough that 10 year olds can understand it, complex enough to remain unsolved for over 50 years now

I've been incredibly lucky to work on many large, collaborative projects in human genomics during my PhD w/Talkowski Lab I wrote an informal blog post on three lessons I've learned, with some (surely naive) thoughts on future directions for our field: scholar.harvard.edu/ryanlcollins/b…

We (Sameer Deshpande, Tamara Broderick and myself) have a new pre-print out now! It’s called “Confidently comparing estimators with the c-value”. arxiv.org/abs/2102.09705

Types of human genetics papers in which I come for all of you and then for myself:

Excited to share our latest manuscript on complex trait fine-mapping across diverse populations! This is a collaborative effort across BioBank Japan FinnGen and UK Biobank with mentorship from Hilary Finucane Mark Daly YukinoriOkada. Here is 🧵 1/n medrxiv.org/content/10.110…

I'm excited to share our new fine-mapping methods: SuSiE-inf and FINEMAP-inf. We improve upon the current state-of-the art methods by modeling infinitesimal effects while fine-mapping larger causal effects. 🧵 1/n biorxiv.org/content/10.110…

Our SLALOM paper is now out in Cell Genomics!🎉 Huge thanks again to Roy Elzur Wei Zhou Mark Daly and Hilary Finucane as well as all the analysts & participants in Global Biobank Meta-analysis Initiative