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Company update: wefunder.com/updates/181373…

Bill Gates on Musk: “The picture of the world’s richest man killing the world’s poorest children is not a pretty one.”

New study: we measured autophagic flux in human blood and compare intermittent fasting with calorie restriction = the largest human autophagy study to date. Although significant, changes in autophagy were modest. #autophagy #fasting #aging SAHMRI physoc.onlinelibrary.wiley.com/doi/10.1113/JP…

NEW STUDY: It's dogma that fasting is good for you because it increases autophagy, the recycling of cell parts. But in the largest study ever, 6 months of time-restricted eating (TRE) or calorie restriction (CR) did not increase autophagy Huh? Is fasting still worth it? ... 🧵

In a recent study published by our group, we measured autophagic flux in human PBMCs. We cannot yet measure #autophagy in organs, which is why we are developing tissue specific autophagy biomarkers.

Thrilled that our Buck team, with partners at Univ of Toulouse, is a semifinalist for the $101M XPRIZE Healthspan. Goal is to restore muscle, cognition and immune function by at least 10 years in people 50+ years old. longevity.technology/news/xprize-he… XPRIZE #xprizehealthspan

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When the most popular longevity interventions (like rapamycin) were tested in mice, specific triglyceride changes were the top predictors of increased lifespan

One of the most exciting thing happening in the aging/longevity field that too few people discuss is that the aggregate pipeline of the entire sector has hit the exciting point where things are trickling thru to FDA approval & many more are on the way. My talk recently posted.

New Research Review: SGLT2 Inhibitors as Metabolic Senolytics: Clearing Senescent Cells to Combat Pathological Aging gethealthspan.com/science/articl…

TRIAD — the Test of Rapamycin in Aging Dogs — is the first-ever veterinary clinical trial focused on slowing aging and extending healthy lifespan in companion dogs. I'm so excited to see dogs completing the trial. This moment has been a long time coming. I first envisioned

Life Expectancy Has Barely Changed in Some US States For More Than a Century : ScienceAlert sciencealert.com/life-expectanc…

What does resilient brain aging look like? Stanford researchers Beth Mormino Mormino Lab and Anthony Wagner share insights from the Stanford Aging and Memory Study, revealing how some people maintain cognitive health well into their 80s and 90s. 🔗 neuroscience.stanford.edu/news/secrets-r…

Just got notice the NIH grant supporting top trainees in my lab working on epigenetic reprogramming to cure diseases that needlessly disable and kill millions of americans a year has been terminated. Pointless and cruel

My partner Serena’s mom is dying from ALS. The NIH grant supporting the scientists in my lab working hard on a cure was just terminated. No words

San Francisco Bay Area Aging Meeting (BAAM), May 27th, 2025. More info: rapamycin.news/t/san-francisc…

Per Boston Globe, ALL Harvard Medical School grants from federal government are cancelled. Here's the pie chart of their budget. The cancellations affect everything, from biostatistics department to longevity researcher David Sinclair. Story from Boston Globe in reply.

The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan | Nature Aging nature.com/articles/s4358…

"Exciting milestones are being celebrated by the Dog Aging Project as the first canine participants graduate from the groundbreaking Test of Rapamycin in Aging Dogs (TRIAD) clinical trial." Read the full article to learn more: citydogmagazine.com/dog-aging-proj… #dogs #DogAgingProject

Nvidia apparently looking to open its first San Francisco office