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NIH Director Dr. Jay Bhattacharya has announced that the NIH Public Access Policy, originally slated to go into effect on 12/31/25 will now be effective 7/1/25. Read more in his statement: bit.ly/4jTQI4O

If you can’t replicate it, it’s not science. If you can’t question it, it’s not science. If you can’t criticize it, it’s a cult.

bad-faith argument👇The hierarchy of evidence is a rough guidance on relative strength of study designs for questions on treatment. Plus, I am not using my personal example as evidence to say this treatment works or not. I am using anecdotal to question: there may be misdiagnosis

Since we are here: do you have high quality evidence (like GRADE methodology you mentioned) to show that the benefits for these treatment strategies outweigh harms? Do you have high quality evidence on the accuracy of diagnosis (again, following GRADE methodology)?

The classic ground-breaking, paradigm-shaking #NEJM article introduced the world to the potential for #RCTs in individual patients - #Nof1 RCTs - to improve #PatientCare. nejm.org/doi/abs/10.105…

There is no contradiction between these two statements: 1. Clinical research should be scrutinized and, if needed, criticized for its flaws. 2. Better-designed studies should be opposed when plausible clinical & ethical rationales for intervention have not been articulated.

ML's Substack is summarizing the HHS report on pediatric gender dysphoria. Part II--Evidence Review--is now available.

quality of evidence is essential. The systematic review needs to tell not only the effect estimates, but also how confident we should be about the effects. The Utah review FAILs to assess the quality/certainty of evidence, using stronger language than it should be.

Review authors can say anything about effect estimates. We should only trust reviews using scientific methods to assess how certain the effect estimates are. The Utah review does not include this process, and its conclusion should NOT be taken as it is without critical appraisal.

I could find reviews saying this treatment works, and reviews saying it does not. I could find people saying it will rain tomorrow, and people saying it will not. Who should I believe? Those following scientific method. Quality of evidence is essential part of scientific method.

HHS sent a letter to health care providers, risk managers, and state medical boards urging immediate updates to treatment protocols for minors with gender dysphoria based on HHS’ comprehensive review that found puberty blockers, cross-sex hormones, and surgeries have very weak

“When we speak we are afraid our words will not be heard nor welcomed, but when we are silent we are still afraid, so it is better to speak.” Audre Lorde

.Helen Lewis in The Atlantic: “Trump’s actions on trans policies reflect a pattern across the administration of chaotic executive orders, inflammatory language, and counterproductive decisions. European reviews have found that American child gender-medicine practices far outstrip

Blew the whistle in Wall Street Journal Opinion on ideological rigidity in therapy training. A week later, I am fired from my internship with the regret of my boss. This field is in crisis. The public needs to know.

James Caspian: “The university said that I couldn’t continue with that research.” Stella O’Malley : “Did they give a reason?” James Caspian: “Because the research might attract criticism on social media, that would be criticism of the university, and that furthermore it is better

At some point you're going to have to learn about the principles of evidence based medicine. I've been asking you to do a systematic review of the evidence for over 5 years. Just because some patients claim the care is life-saving does not make that true, this is how scandals go.

🚨Big opinion pieces today. Gay rights veteran Andrew Sullivan in New York Times Opinion: The LGBT movement has radicalized and drifted into “madness.” In Washington Post Opinions Alex Byrne confirms he coauthored the HHS report on gender dysphoria, urges fellow liberals to take it seriously. Links ⬇️

MIT philosophy professor Alex Byrne confirms he coauthored the HHS report on pediatric gender dysphoria and explains why fellow liberals should take it seriously: washingtonpost.com/opinions/2025/…