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What if we could universally recombine, insert, delete, or invert any two pieces of DNA? In back-to-back nature papers, we report the discovery of bridge RNAs and 3 atomic structures of the first natural RNA-guided recombinase - a new mechanism for programmable genome design

We performed subtomogram averaging on complexes from >3 MDa to ~200 kDa, including 80S ribosomes, Rubisco, clathrin, microtubules, ATP synthase photosystem II, and nucleosomes. Most density maps achieved sub-nanometer resolution!🔬✨ #CryoET #StructuralBiology #VisualProteomics

Gordon looks beyond native DNA and RNA sequencing - highlighting a future where genomics meets proteomics. Read why he says combining these fields in the future “will be a thing of beauty.”: bit.ly/40HTEtI

Our research group at Human Technopole , supported by European Research Council (ERC) aims to unravel the molecular mysteries of #thyroid hormone signalling. We seek for a passionate Postdoc to redefine paradigms in thyroid cell biology&disease 👉Apply now! lnkd.in/dbk_ePxH

Fantastic opportunity!

Crystal structures are *not* God-given truth. They approximate, w/ flaws & errors, X-ray diffraction data. AlphaFold etc. have been trained on structures, not data. SFCalculator now differentiably connects structures to diffraction data. What does this enable? 🧵 1/4

💛LoVis4u - a visualisation tool for comparative genomics and sequencing coverage profiles is now published! See our paper in NAR GB: doi.org/10.1093/nargab…

Please spread the word! We have an opening in the Atkinson lab for a post-doc with a focus on molecular mechanisms of microbial immune systems. Can be a fully computational or experimental or hybrid project. Read more & apply here: lu.varbi.com/en/what:job/jo… #phage #Bioinformatics

A recent news/views article about our nanopore rare earth element sensing work published at Nature Nanotechnology. Thanks Andrew Laszlo for your comments, really supportive and inspiring 😊😊. There are plenty of room for nanopore beyond sequencing. nature.com/articles/s4156…

New paper alert 🚨 We've solved the complete structure of a C. difficile-infecting phage using cryo-EM, in both extended and contracted conformations - published today in Life Science Alliance

New Huang lab publication. A comprehensive review of nanopore environmental analysis. And, it is open access, which should be convinient for most readers. pubs.acs.org/doi/10.1021/ja…

12 lessons students learn in the Sinclair Lab: Lesson 1. Write the way you speak

I'm happy to see our collaboration with PHAGEBio lone brøndsted out on npj viruses! I had a fun time modelling T-even #phages adhesin proteins. Verifying that we can use #AF2 bias to select true binders was even cooler. Congrats to Veronika Lutz and all nature.com/articles/s4429…

You want to start tomography? Solve structures inside cells? Reach Nyquist😳? We have a website for you! tomoguide.github.io You'll find a tutorial on how to reconstruct tomograms, pick particles and do subtomo averaging, using different software! Hope it will be useful !

There is also a Colab notebook for EvoBindRare now! Try it and let us know what you think: colab.research.google.com/github/patrick…

New pre-print - 🥳🥳🥳 biorxiv.org/content/10.110…

Exited to share our preprint on the structure of a Salmonella contractile injection system 🥳 Wonderful work by first author Rooshanie Ejaz Ejaz and Claudia Kielkopf, Freddie Martin, Marta Siborova, Eva Maria Steiner-Rebrova 🇺🇦🇦🇹🇸🇪, great collab with Marc Erhardt CPRatUCPH #cryoem shorturl.at/QHLpm

Excited to see our work published in Science Advances! We present RBPseg, a method for structural prediction of #phage receptor-binding proteins. We applied it to diverse tail fibers and validated the predicted structures using #cryoEM. Read here: science.org/doi/10.1126/sc…

Boltz-2 was released recently. It is an Open Source protein-ligand co-folding model, which means it can predict the structure of a protein along with the ligand. It has various applications from drug discovery to protein design. I thought why not make a OSS web app for it.

Excited to share #AlphaGenome, a start of our AlphaGenome named journey to decipher the regulatory genome! The model matches or exceeds top-performing external models on 24 out of 26 variant evaluations, across a wide range of biological modalities.1/6