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subtomogram averaging is difficult...

こいつもS1P1タイプ。未だに脂質受容体は気になっちゃう。 Structures of the Human PGD2 Receptor CRTH2 Reveal Novel Mechanisms for Ligand Recognition cell.com/molecular-cell…

鍋で米が炊けた！！！水の量カンで決めたけど、なんとかなる。Sushi reis最強。500 gで2ユーロしないから、実はかなり安い？

だおだおまん、師匠、2438さん、おめでとうございます！お疲れ様でした。 nature.com/articles/s4146…

On my way to the #3DEMGRC. The gist of my poster is: The Volta phase plate does not provide any practical benefits for determining the structure of GPCRs. Conclusion: Stop using the VPP and focus on improving your samples. 🙂👍🔬

Our paper showing two distinct conformations of hNTSR1(human neurotensin receptor type 1)-Gi1 complex is out now in nature! Great collaboration with Skiniotis, Dror, and Junken labs! nature.com/articles/s4158…

Scienceなう(^^)/ science.sciencemag.org/content/early/…

How do you make nuclear pores away from the nucleus? Our paper online today bit.ly/AL-NPC EMBL @A_Schw @SchwabYannick Cell #development #Nuclearpores #microscopy bit.ly/AL-NPC 1/11 [a thread]

Our work on in-cell architecture of the nuclear pore complex is on bioarxiv! @Christ_Zimmerli Beck Laboratory Jan Kosinski @WilflingFlorian @SchwabYannick disq.us/t/3lvufg3

Structure and mechanism of a primate ferroportin biorxiv.org/cgi/content/sh… #bioRxiv

ビビりなだけかもしれんが、まわりで１日に数百単位で感染者が増えてくのは、シンプルに怖い。感染する怖さ、というより、コントロールできてない、歯止めが利かなくなってる怖さの方だと思う。地続きな領域間での国境閉鎖ってのも、事態の不穏さに拍車をかけている気がする。

本日よりa few weeks (詳細未定)のhome office. 欠けていたInputの時間として前向きに捉える所存。。。

(1/2) Our large #cryoET dataset of #SARSCoV2 will be available soon on EMPIAR-10453. Thanks to Krijnse Locker, Jacomine, Hummer teams Paul-Ehrlich-Institut & Max Planck Institute of Biophysics, #cryoEM EMBL and everyone involved in this collaborative effort. #TeamTomo biorxiv.org/content/10.110…

構造予測すごいけど、予測できることよりも高精度の予測にとって何が一番criticalだったのかを理解することが科学的には重要な気がするし、その辺の検証を欠いたらただの便利ツールで終わるのでは、というのが色々考えた上での個人的意見。

(1/6) Work by Christian Zimmerli and @MatteoFFM in collaboration with Jan Kosinski, Julia Mahamid and Hummer Lab published today Science Magazine reveals that nuclear pores are mechanosensitive. They dilate and constrict in living cells. science.org/doi/10.1126/sc…

How can genetic perturbation of a central scaffolding component of the #nuclearpore result in a tissue specific defect? Work by Reiya_Taniguchi and others in collaboration with Valerie Doye makes this more conceivable (Max Planck Institute of Biophysics Institut Jacques Monod): biorxiv.org/content/10.110…

Happy to finally share our preprint about NPC scaffold integrity and its perturbation! Could not have been achieved without all the helps from co-authors and colleagues in Beck Laboratory, especially Martin and our collaborator Valerie Doye. biorxiv.org/content/10.110…