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We're looking for a PhD student interesting in protein design and tech development. Exciting project interfacing protein VIB_StructuralBiologyBrussels and solid-state nanopores imec. Computational design of hybrid nanopore sensors. Apply by December 15th! imec-int.com/en/work-at-ime…

Interested in membrane protein structure, folding, interactions and function? We're looking for a creative, talented post-doc to join our bacterial outer membrane team RadfordLab Neil Ranson in the The Astbury Centre, on a new Medical Research Council programme grant. jobs.leeds.ac.uk/Vacancy.aspx?r…

Looking for a postdoc excited about the structural biology of bacterial biofilms and cyclic dinucleotide signaling. We are a small but diverse and passionate team, have access to high-end facilities and provide hands-on training in a variety of techniques. Repost & DM 🙏🙏🙏

This #preprint by Jolyon Claridge, Han Remaut, Mike Sleutel, and colleagues VUB has recently been reviewed by Biophysics Colab You can read the report by clicking on 'TRiP Peer Reviews' in bioRxiv: biorxiv.org/content/10.110…

Happy to see the L-ENA story make its way to the Nature Communications website. Great collaboration with NMBU Oslo. VIB VUB nature.com/articles/s4146…

Published today in nature, we describe an approach for single-molecule protein reading on Oxford Nanopore arrays. By utilizing ClpX unfoldase to ratchet proteins through a CsgG nanopore, we achieved single-amino-acid sensitivity. nature.com/articles/s4158…

His accuracy is 100/100

Post doc in cryo EM of Amyloid- with Neil Ranson and The Astbury Centre- an exciting opportunity for you to join our collegiate and inspiring team trying to crack amyloid disease by better understanding its formation from test tubes to tissues. Apply here jobs.leeds.ac.uk/Vacancy.aspx?r…

I had a great time discussing functional amyloids and presenting my work on #EngineeredLivingMaterials at Vrije Universiteit Brussel VUB Thanks, Han Remaut, for hosting me!

🎉 Super excited to announce that our study "Colibactin-driven colon cancer requires adhesin-mediated epithelial binding" is now published in Nature! Huge congratulations to first authors Maude Jans and Magdalena Kolata for their fantastic work! 1/6🧵🎉 nature.com/articles/s4158…

2/6 Our study reveals that the adhesins FimH and FmlH are critical for pks⁺ E. coli to bind epithelial cells, enabling colibactin production in close proximity to host DNA. This binding significantly amplifies DNA damage, driving colon cancer development. 🦠🔬

3/6 Pharmacological inhibition of FimH effectively blocks bacterial binding, reducing genotoxicity and colon cancer progression. This targeted approach spares beneficial gut microbes, offering a promising therapeutic strategy without the drawbacks of antibiotics. 🚫💊

4/6 🚨 Our findings raise concerns about using E. coli Nissle 1917 as a probiotic. Minimal mutations in Nissle FimH can transform this pks⁺ strain into a highly genotoxic one, potentially increasing cancer risk. A re-evaluation of its safety as a probiotic may be warranted. 🧬⚠️

5/6 This was a fantastic collaboration with the Han Remaut lab. Thanks to all who contributed to this work, including Iliev Lab, Johan VV, sabine Tejpar, Geert Berx 🙏🙏🙏

6/6 Special thanks to StichtingtegenKanker , FWO , VIB , CRIG, UGent ,VUB and IRC - VIB/UGent for funding and supporting our work. 🧪🙏🙏

🔍 Huge thanks to @kyannaouyang and Jens Puschhof for their insightful News and Views perspective on our study! 🙏🤩 nature.com/articles/d4158…

The feeling is completely reciprocal, absolute pleasure and boost to collaborate with Lars Vereecke lab

🤯 Specific strains of 𝘌. 𝘤𝘰𝘭𝘪 might contribute to colon cancer. Lars Vereecke Han Remaut Maude Jans Magdalena Kolata and colleagues figure out how. ➡️ Read here vibbio.tech/4hDcYQo IRC - VIB/UGent VIB_StructuralBiologyBrussels UGent VUB FWO StichtingtegenKanker CRIG

Great opportunity to join the Radford / Ranson labs and the world-renowned Astbury Centre as a Research Fellow in Structural Biology! Please see jobs.leeds.ac.uk/vacancy.aspx?r…

Han Remaut José R Penadés Thanks, Han! More exciting news coming next week!