1/2 In 2020, a Lancet report highlighted 12 modifiable key risk factors for #dementia (e.g., traumatic brain injury [TBI], air pollution, loneliness, education, #diabetes, and genetics); some of these factors are being pursued as points of intervention for #dementia. @HarvardMS

Evaluation of the heterogeneity of odds ratios for 12 risk factors reported from the Lancet 2020 report and two non-modifiable factors on dementia. Read the full study here: bmcmedicine.biomedcentral.com/articles/10.11… Renhao Dena Zeraatkar Maria Glymour Randy Ellis hōssein estiri Chirag Patel.

Haven't we learned anything about stopping pandemics? When it comes to government policy and COVID-19, the answer is: "no, we don't have the data." I write an op-ed with Eran Bendavid in STAT: statnews.com/?p=1165584 about our research paper in Science Advances:

Our second years Allison Barkdull, @YutingZhan8328, and Renhao received lab coats this weekend! #computationalscientists #whataretheygonnadowithlabcoats

Looking to hire scientists (at all levels) to develop new computational models and AI approaches to map the exposome! Data across multiple scales are staged and ready to analyze! 🤓💻 check out: bit.ly/patelgrouphire and DM or email! hōssein estiri Arjun (Raj) Manrai

Interested in diffusion models, behavior forecasting, internal states, neuromechanical modeling, reservoir computing, joint neural/behavioral datasets? Missing the sunshine? We have multiple fully funded postdoc positions, come join us!

While exercise has long been known to benefit the brain, the specific cells responsible remained unclear—until now. Learn about new research from Mass General Brigham Research and Upstate Medical University, and its connection to Alzheimer's disease. spklr.io/6010B6Wan

Heartbroken to share my mentor & friend Dr. Atul J. Butte Atul Butte has passed. He saw potential in me and turned it into opportunity-- for me, and so many others. We bonded over Star Trek and he was our Captain. Picard’s parting toast in his honor, final episode:

Protective exercise responses in the dentate gyrus of Alzheimer’s disease mouse model revealed with single-nucleus RNA-sequencing Christiane Wrann, PhD, DVM, Mass General Brigham Research, Nathan Tucker, Mark Gittner nature.com/articles/s4159…

New research in Science greatly expands the potential target scope of molecular glues and should stimulate the development of new small molecules that can selectively target therapeutically relevant proteins for degradation. Learn more in this week's issue:

Over the last 6 years we Monte Rosa Therapeutics, Inc have pushed the limits on molecular glue degrader design. The term MGD didn’t even exist 6 years ago! Very proud of the team and exited about what the technology holds! Go QuEEN! Aye-Oh!

Incredible effort from @bradentierney and I am honored to continue to work with him. Imagine the medicines we might be able to mine or toxicants removed from harms way? nytimes.com/2025/10/06/cli… Harvard Medical School The Two Frontiers Project The New York Times 💪